{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00520, a long intergenic non‐protein coding RNA located on chromosome 14q22.3, has emerged as a critical regulator in a range of pathological conditions. In multiple cancers—including breast, melanoma, lung (both non‐small cell and adenocarcinoma), nasopharyngeal, hepatocellular, glioma, colorectal, and head and neck squamous cell carcinoma—LINC00520 is frequently overexpressed and is strongly associated with advanced tumor stage, poor prognosis, and enhanced cell proliferation, migration, invasion, and metastasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": " Mechanistic studies have revealed that LINC00520 largely exerts its oncogenic influence by acting as a competing endogenous RNA; it sequesters diverse microRNAs—including miR-27b-3p, miR-1252-5p, miR-3611, miR-520f-3p, miR-26b-3p, miR-577, let-7a-5p, and miR-195—to modulate the expression of key downstream targets such as OSMR, EIF5A2, USP39, HSP27, FOXP3, CCNE2, and TFAP4 in context-specific regulatory loops."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}, {"type": "fg_fs", "start_ref": "3", "end_ref": "7"}, {"type": "fg_f", "ref": "10"}, {"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In addition, genetic variants within LINC00520 have been linked to altered susceptibility and molecular subtypes in breast cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ", while its aberrant expression has also been implicated in modulating radiosensitivity in head and neck tumors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Beyond cancer, LINC00520 contributes to the exacerbation of acute kidney injury through activation of the PI3K/AKT pathway and has even been proposed as a potential non-invasive biomarker in renal cell carcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}, {"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " Collectively, these findings establish LINC00520 as a multifaceted regulator of gene expression via ceRNA mechanisms and underscore its promise as both a prognostic biomarker and a therapeutic target across diverse human diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xue-Ling Mei, Shan Zhong "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LINC00520 prevents the progression of cutaneous squamous cell carcinoma through the inactivation of the PI3K/Akt signaling pathway by downregulating EGFR."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Chin Med J (Engl) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/CM9.0000000000000070"}], "href": "https://doi.org/10.1097/CM9.0000000000000070"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30707166"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30707166"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Whitney S Henry, David G Hendrickson, Francisco Beca, et al. 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