{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00524, a long non‐coding RNA, has recently emerged as a critical component in the prognostic assessment of clear cell renal cell carcinoma (ccRCC). Comprehensive analyses of lncRNA expression profiles from public databases (The Cancer Genome Atlas and the International Cancer Genome Consortium) have demonstrated that LINC00524, as part of a multi‐lncRNA signature, is significantly associated with overall survival in ccRCC patients. Its inclusion in risk models and prognostic nomograms has improved the predictive accuracy for 3‐ and 5‐year survival outcomes, highlighting its potential utility as a biomarker in ccRCC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, insights from functional enrichment analyses suggest that LINC00524 may be involved in molecular mechanisms related to tumor progression, particularly through pathways such as the PI3K‐Akt‐mTOR and hypoxia‐inducible factor signaling networks. While the broad regulatory roles of lncRNAs in various malignancies, including non‐small cell lung cancer, have been well documented"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", the findings in ccRCC underscore the emerging importance of LINC00524 as a prognostic factor and potential therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sheng Wang, Kequn Chai, Jiabin Chen "}, {"type": "b", "children": [{"type": "t", "text": "A novel prognostic nomogram based on 5 long non-coding RNAs in clear cell renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Lett (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ol.2019.11009"}], "href": "https://doi.org/10.3892/ol.2019.11009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31788117"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31788117"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chuanjie Zhang, Da Huang, Ao Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide screening and cohorts validation identifying novel lncRNAs as prognostic biomarkers for clear cell renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.29478"}], "href": "https://doi.org/10.1002/jcb.29478"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31646670"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31646670"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yachen Zhang, Di Liang, Jing Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Progress of Long Non-coding RNA in Non-small Cell Lung Cancer]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhongguo Fei Ai Za Zhi (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3779/j.issn.1009-3419.2018.01.06"}], "href": "https://doi.org/10.3779/j.issn.1009-3419.2018.01.06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29357972"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29357972"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sonia Molina-Pinelo, Ana Salinas, Nicolás Moreno-Mata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Impact of DLK1-DIO3 imprinted cluster hypomethylation in smoker patients with lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.10611"}], "href": "https://doi.org/10.18632/oncotarget.10611"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29435111"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29435111"}]}]}]}