{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00526 is a long noncoding RNA that has been implicated in tumor suppression in glioma and may serve as a prognostic biomarker in other cancers such as bladder cancer. In glioma, LINC00526 is significantly downregulated, and its reduced expression is associated with increased tumor aggressiveness and poorer overall survival. Functional studies have demonstrated that restoring LINC00526 levels inhibits glioma cell proliferation, migration, and invasion. Mechanistically, LINC00526 directly interacts with EZH2 to reduce its occupancy at the AXL promoter, leading to decreased AXL transcription and subsequent attenuation of the PI3K/Akt/NF-κB signaling pathway. This interaction contributes to the formation of a double negative feedback loop that is critical in mediating its tumor‐suppressive effects."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, integrative analyses in bladder cancer have identified LINC00526 as one of a panel of six methylation‐driven genes that can stratify patient prognosis. Aberrant DNA methylation patterns involving LINC00526 correlate with altered gene expression and clinical outcomes, supporting its potential utility as a prognostic indicator in this context."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies suggest that LINC00526 functions as a tumor suppressor through modulation of key oncogenic signaling pathways and holds promise as both a biomarker and a therapeutic candidate in glioma and possibly other cancers.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jian Yan, Chunhua Xu, Youping Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC00526 represses glioma progression via forming a double negative feedback loop with AXL."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.14435"}], "href": "https://doi.org/10.1111/jcmm.14435"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31240814"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31240814"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jian Yan, Youping Li, Chunhua Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA LINC00526 Represses Glioma Progression via Regulating miR-5581-3p/BEX1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/8171250"}], "href": "https://doi.org/10.1155/2021/8171250"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33613672"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33613672"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Liwei Wang, Jiazhong Shi, Yaqin Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A six-gene prognostic model predicts overall survival in bladder cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-019-0950-7"}], "href": "https://doi.org/10.1186/s12935-019-0950-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31516386"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31516386"}]}]}]}