{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00528 has emerged as an important regulatory long noncoding RNA implicated in diverse disease settings. In the context of myocardial infarction (MI), one study demonstrated that LINC00528 is upregulated in post‐MI cells where it helps modulate the inflammatory response and cell fate. Mechanistically, LINC00528 was shown to interact with miR‑143‑3p, thereby regulating the expression of COX‑2; suppression of LINC00528 resulted in enhanced cell proliferation and reduced apoptosis, suggesting that it may contribute to the progression of MI via the miR‑143‑3p/COX‑2 axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Complementary computational analyses of circulating endothelial cell expression profiles in acute MI also identified key lncRNAs involved in inflammatory response pathways, lending further support to the notion that regulatory noncoding RNAs—potentially including LINC00528—play a critical role in MI pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In a separate oncological context, LINC00528 has been incorporated into a prognostic risk model for laryngeal squamous cell carcinoma (LSCC). Analysis of patient datasets from The Cancer Genome Atlas revealed that LINC00528, together with several other lncRNAs, was associated with clinical parameters such as tumor stage and gender. Moreover, co-expression network analyses identified potential protein‐coding gene targets whose expression correlated with overall survival in LSCC patients. These findings suggest that LINC00528 may serve not only as a biomarker for disease prognosis but also as a candidate for targeted studies in LSCC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Although another abstract was provided, it did not include specific details regarding LINC00528.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies highlight that LINC00528 functions as a regulatory RNA capable of influencing key molecular pathways in both cardiovascular disease and cancer, making it a potential target for future therapeutic interventions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ketong Liu, Di Zhao, Di Wang "}, {"type": "b", "children": [{"type": "t", "text": "LINC00528 regulates myocardial infarction by targeting the miR-143-3p/COX-2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2019.1704535"}], "href": "https://doi.org/10.1080/21655979.2019.1704535"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31833800"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31833800"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaodong Sheng, Tao Fan, Xiaoqi Jin "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Key Genes Involved in Acute Myocardial Infarction by Comparative Transcriptome Analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/1470867"}], "href": "https://doi.org/10.1155/2020/1470867"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33083450"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33083450"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Shiqi Gong, Meng Xu, Yiyun Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Prognostic Signature and Potential Target Genes of Six Long Non-coding RNA in Laryngeal Squamous Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2020.00413"}], "href": "https://doi.org/10.3389/fgene.2020.00413"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32411183"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32411183"}]}]}]}