{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have demonstrated that tumor‐educated platelets are a promising source of diagnostic biomarkers in colorectal cancer (CRC). In this context, a panel of platelet‐associated long non‐coding RNAs was evaluated, in which LINC00534, along with LNCAROD, SNHG20, and TSPOAP‐AS1, was found to be significantly upregulated in both platelets and serum samples of CRC patients. The upregulation of LINC00534 contributes to a diagnostic model that achieved an area under the ROC curve of 0.78, underscoring its potential utility in non‐invasive CRC diagnostics. These findings also support the concept of cross-talk between CRC-affected platelets and serum RNA profiles, suggesting that LINC00534 may serve as a valuable biomarker within a broader lncRNA panel for effective disease detection."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Bingqi Ye, Fengying Li, Mengsha Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A panel of platelet-associated circulating long non-coding RNAs as potential biomarkers for colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genomics (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygeno.2021.11.026"}], "href": "https://doi.org/10.1016/j.ygeno.2021.11.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34843904"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34843904"}]}]}]}