LINC00535 Gene

Name long intergenic non-protein coding RNA 535
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00535 is a long non‐coding RNA that has been implicated in diverse biological processes and disease contexts. In studies investigating human germ cell development, LINC00535 was among a panel of lncRNAs that exhibited consistent differential expression in spermatogenesis, suggesting it may play a role in regulating genes essential for proper germ cell function and male fertility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, analysis of Wilms tumor patient samples revealed that high expression of LINC00535 is associated with poor overall survival, implying an oncogenic function and its potential utility as a prognostic biomarker in pediatric kidney cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Collectively, these findings highlight the multifaceted roles of LINC00535 in both normal developmental processes such as spermatogenesis and in tumor progression, suggesting it may contribute to critical regulatory networks in different biological settings.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Meghali Joshi, Singh Rajender "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNAs (lncRNAs) in spermatogenesis and male infertility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Biol Endocrinol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12958-020-00660-6"}], "href": "https://doi.org/10.1186/s12958-020-00660-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33126901"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33126901"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hong Zheng, Bai-Hui Li, Chang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive Analysis of lncRNA-Mediated ceRNA Crosstalk and Identification of Prognostic Biomarkers in Wilms' Tumor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/4951692"}], "href": "https://doi.org/10.1155/2020/4951692"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32149111"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32149111"}]}]}]}
NCBI Gene ID 642924
API
Download Associations
Predicted Functions View LINC00535's ARCHS4 Predicted Functions.
Co-expressed Genes View LINC00535's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View LINC00535's ARCHS4 Predicted Functions.

Functional Associations

LINC00535 has 1,643 functional associations with biological entities spanning 6 categories (molecular profile, organism, disease, phenotype or trait, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 20 datasets.

Click the + buttons to view associations for LINC00535 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq tissue samples with high or low expression of LINC00535 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00535 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of LINC00535 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00535 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at LINC00535 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of LINC00535 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of LINC00535 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of LINC00535 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of LINC00535 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of LINC00535 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of LINC00535 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of LINC00535 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of LINC00535 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
GWASdb SNP-Disease Associations diseases associated with LINC00535 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.
GWASdb SNP-Phenotype Associations phenotypes associated with LINC00535 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00535 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
LOCATE Predicted Protein Localization Annotations cellular components predicted to contain LINC00535 protein from the LOCATE Predicted Protein Localization Annotations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of LINC00535 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of LINC00535 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at LINC00535 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.