{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have uncovered an emerging oncogenic role for the long non‐coding RNA LINC00536 in various cancer types. In bladder cancer, LINC00536 is highly expressed in tumor tissues compared with normal controls, and its upregulation is associated with a lower survival rate. Functional experiments demonstrated that overexpression of LINC00536 promotes cell proliferation, migration, and invasion, at least in part by activating the Wnt3a/β‑catenin signaling pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In hepatocellular carcinoma, LINC00536 is also overexpressed in tumor samples and correlates with poor prognosis. Mechanistically, LINC00536 acts as a competing endogenous RNA by binding to miR‑203b‑5p, thereby decreasing miR‑203b‑5p levels and, in turn, allowing upregulation of its target gene VEGFA, which promotes malignant progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Furthermore, a chromosomal translocation disrupting LINC00536 has been identified in a patient with clinical features overlapping with Trichorhinophalangeal syndrome, suggesting that alterations in the genomic architecture involving LINC00536 may affect the cis‑regulation of neighboring genes such as TRPS1, contributing to disease pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In breast cancer, bioinformatics‐based ceRNA network analyses have incorporated LINC00536 as a component of multi‑lncRNA prognostic signatures. Its differential expression is significantly associated with overall survival, reinforcing the notion that LINC00536 may serve as an independent prognostic biomarker and participate in oncogenic regulatory networks."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings indicate that LINC00536 contributes to tumor progression through multiple mechanisms—ranging from activation of key signaling pathways to modulation of microRNA regulatory networks—and underscore its potential as both a prognostic marker and a therapeutic target in cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ran Li, Lei Zhang, Zhiqiang Qin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High LINC00536 expression promotes tumor progression and poor prognosis in bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2019.03.009"}], "href": "https://doi.org/10.1016/j.yexcr.2019.03.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30851243"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30851243"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Li-Gang Wang, Hai-Yang Song, Kun-Peng Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00536 promotes hepatocellular carcinoma progression via the miR-203b-5p/VEGFA axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasma (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4149/neo_2021_210815N1158"}], "href": "https://doi.org/10.4149/neo_2021_210815N1158"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34881629"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34881629"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Milena Crippa, Ilaria Bestetti, Mario Perotti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "New case of trichorinophalangeal syndrome-like phenotype with a de novo t(2;8)(p16.1;q23.3) translocation which does not disrupt the TRPS1 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Med Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2350-15-52"}], "href": "https://doi.org/10.1186/1471-2350-15-52"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24886451"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24886451"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Chun-Ni Fan, Lei Ma, Ning Liu "}, {"type": "b", "children": [{"type": "t", "text": "Systematic analysis of lncRNA-miRNA-mRNA competing endogenous RNA network identifies four-lncRNA signature as a prognostic biomarker for breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-018-1640-2"}], "href": "https://doi.org/10.1186/s12967-018-1640-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30261893"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30261893"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jing-Jing Wang, Yue-Qing Huang, Wei Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive analysis of the lncRNA‑associated competing endogenous RNA network in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2019.7374"}], "href": "https://doi.org/10.3892/or.2019.7374"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31638237"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31638237"}]}]}]}