LINC00543 Gene

Name long intergenic non-protein coding RNA 543
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent research has implicated the long non‐coding RNA LINC00543 as an important regulator of cellular processes implicated in oncogenesis. In particular, findings in Abstract"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "indicate that LINC00543 may function as a competing endogenous RNA, sequestering specific microRNAs and thereby modulating the expression of key genes involved in cell proliferation, migration, and apoptosis. Through these interactions, LINC00543 appears to influence downstream signaling pathways that contribute to tumor progression, suggesting its potential utility both as a biomarker for disease prognosis and as a candidate therapeutic target. Collectively, these observations underscore a pivotal role for LINC00543 in the regulation of cellular homeostasis and cancer development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jun-Nan Guo, Tian-Yi Xia, Shen-Hui Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic Immunity and Therapeutic Sensitivity Analyses Based on Differential Genomic Instability-Associated LncRNAs in Left- and Right-Sided Colon Adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Mol Biosci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fmolb.2021.668888"}], "href": "https://doi.org/10.3389/fmolb.2021.668888"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34532341"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34532341"}]}]}]}
NCBI Gene ID 100132234
API
Download Associations
Predicted Functions View LINC00543's ARCHS4 Predicted Functions.
Co-expressed Genes View LINC00543's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View LINC00543's ARCHS4 Predicted Functions.

Functional Associations

LINC00543 has 233 functional associations with biological entities spanning 3 categories (organism, disease, phenotype or trait, cell line, cell type or tissue) extracted from 6 datasets.

Click the + buttons to view associations for LINC00543 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles tissues with high or low expression of LINC00543 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of LINC00543 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of LINC00543 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of LINC00543 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of LINC00543 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00543 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.