{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Among the studies provided, only one directly evaluated long non‐coding RNAs (lncRNAs) in a tumor context and identified LINC00547 as part of a six‐lncRNA signature with prognostic significance in esophageal squamous cell carcinoma (ESCC)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although the study did not dissect the molecular mechanism of LINC00547, its inclusion in this robust prognostic panel suggests that it may contribute to tumor progression, influence patient survival, or serve as a valuable biomarker when combined with established clinicopathological factors. In contrast, the other two abstracts focused on identifying genomic alterations and risk factors across various disorders—basal cell carcinoma and breast cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "as well as subclinical atherosclerosis in individuals with type 2 diabetes"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "—thereby highlighting how diverse genomic features, including lncRNAs, might be harnessed to improve disease classification and prognostication. Collectively, these studies underscore the emerging interest in non‐coding RNAs such as LINC00547 and advocate for further investigation into their functional roles in cancer progression and their potential utility as auxiliary prognostic biomarkers.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ze-Jun Zheng, Yan-Shang Li, Jun-De Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Construction of the Six-lncRNA Prognosis Signature as a Novel Biomarker in Esophageal Squamous Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2022.839589"}], "href": "https://doi.org/10.3389/fgene.2022.839589"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35432441"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35432441"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Alessandra Morelle, Rodrigo Cericatto, Ana Cristina Victorino Krepischi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical and genetic characterization of basal cell carcinoma and breast cancer in a single patient."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Springerplus (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/2193-1801-3-454"}], "href": "https://doi.org/10.1186/2193-1801-3-454"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25184114"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25184114"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yingchang Lu, Latchezar Dimitrov, Shyh-Huei Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multiethnic Genome-Wide Association Study of Subclinical Atherosclerosis in Individuals With Type 2 Diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Genom Precis Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCGEN.120.003258"}], "href": "https://doi.org/10.1161/CIRCGEN.120.003258"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34241534"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34241534"}]}]}]}