{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The reviewed studies address genomic factors in two distinct disorders – Alzheimer’s disease and immunoglobulin light chain (AL) amyloidosis – yet neither abstract provides any functional insights regarding LINC00550. In the first study, an ordered‐subset analysis based on age at onset uncovered several loci linked to Alzheimer’s disease, notably identifying the chr15:30,44 region that harbors CHRFAM7A. This gene acts as a dominant negative regulator of CHRNA7 function, which is involved in amyloid‐β1–42 internalization, thereby implicating a mechanism in Alzheimer’s disease pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In parallel, the second study focused on AL amyloidosis by evaluating copy number alterations in plasma cell samples, highlighting the genomic alterations that contribute to the pathological deposition of amyloid fibrils and subsequent organ dysfunction."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Although both investigations contribute valuable insights into the genetic landscapes of their respective diseases, neither study discusses or characterizes the function of the long non‐coding RNA LINC00550. Thus, the role of LINC00550 remains to be elucidated in these and potentially other disease contexts.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kinga Szigeti, Blanka Kellermayer, Jenna M Lentini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ordered subset analysis of copy number variation association with age at onset of Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Alzheimers Dis (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/JAD-132693"}], "href": "https://doi.org/10.3233/JAD-132693"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24787912"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24787912"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Martin Granzow, Ute Hegenbart, Katrin Hinderhofer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel recurrent chromosomal aberrations detected in clonal plasma cells of light chain amyloidosis patients show potential adverse prognostic effect: first results from a genome-wide copy number array analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Haematologica (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3324/haematol.2016.160721"}], "href": "https://doi.org/10.3324/haematol.2016.160721"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28341732"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28341732"}]}]}]}