{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have revealed context‐dependent roles for the long noncoding RNA LINC00551 in tumorigenesis. In non–small cell lung cancer, for example, LINC00551 (reported in one study as LINC00511) is upregulated and its elevated expression is associated with larger tumor size, advanced stage, lymph node and distant metastasis, as well as reduced overall survival. Functionally, LINC00551 promotes cell proliferation, invasion, and migration while inhibiting apoptosis. Mechanistic investigations indicate that it localizes predominantly to the nucleus where it interacts directly with epigenetic modifiers—LSD1 and EZH2—to bind the promoters of tumor‐suppressive genes such as LATS2 and KLF2, thereby repressing their expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In contrast, studies in esophageal squamous cell carcinoma have shown that LINC00551 is markedly downregulated. Lower expression levels of this lncRNA correlate with lymph node metastasis, larger tumor size, advanced TNM stage, and poorer progression‐free and overall survival. In vitro and in vivo functional assays demonstrated that overexpression of LINC00551 inhibits cell proliferation and invasion. At the molecular level, LINC00551 appears to exert its tumor‐suppressive effects by binding to the heat shock protein HSP27 and reducing its phosphorylation, thereby attenuating oncogenic signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, large‐scale transcriptomic analyses in other conditions—such as oral submucous fibrosis and lung adenocarcinoma—emphasize the broader role of dysregulated lncRNAs in modulating key signaling pathways (including Wnt, p53, and EGFR) that drive malignant progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings underscore the multifaceted and context‐specific functions of LINC00551 in cancer. Depending on the tumor type, it may act either as an oncogenic driver or as a tumor suppressor. As such, LINC00551 represents a promising candidate for further investigation as a prognostic biomarker and potential therapeutic target in diverse malignancies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "F-Y Zhu, S-R Zhang, L-H Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00511 promotes the progression of non-small cell lung cancer through downregulating LATS2 and KLF2 by binding to EZH2 and LSD1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201910_19149"}], "href": "https://doi.org/10.26355/eurrev_201910_19149"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31646568"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31646568"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiong Peng, Yuan Zhou, Yuqiao Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduced LINC00551 expression promotes proliferation and invasion of esophageal squamous cancer by increase in HSP27 phosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29947"}], "href": "https://doi.org/10.1002/jcp.29947"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32677057"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32677057"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Shanghui Zhou, Yun Zhu, Zhijing He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Non-Coding RNA Expression Profile Associated with Malignant Progression of Oral Submucous Fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Oncol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2019/6835176"}], "href": "https://doi.org/10.1155/2019/6835176"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31467541"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31467541"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Li Wang, Huishan Wang, Bining Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "LINC00551"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Suppresses Glycolysis and Tumor Progression by Regulating "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "c-Myc"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "-Mediated "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "PKM2"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Expression in Lung Adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S273797"}], "href": "https://doi.org/10.2147/OTT.S273797"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33204101"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33204101"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Unknown Authors "}, {"type": "b", "children": [{"type": "t", "text": "CORRIGENDUM: Reduced LINC00551 expression promotes proliferation and invasion of esophageal squamous cancer by increase in HSP27 phosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.30636"}], "href": "https://doi.org/10.1002/jcp.30636"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34792192"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34792192"}]}]}]}