{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough none of the studies provided address LINC00554 directly, they collectively delineate the multifaceted roles of semaphorin 4D (Sema4D, also known as CD100) and its receptors as master regulators of diverse cellular processes. In the nervous system, Sema4D contributes to axonal guidance, modulates neurite outgrowth, and influences oligodendrocyte survival and differentiation—functions that are essential for proper neural circuit formation as well as for regenerative responses following injury."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its neural functions, Sema4D exerts potent effects in nonneuronal tissues. It acts as a critical mediator in the immune system by promoting T-cell activation, fine-tuning B-cell receptor signaling, and enhancing dendritic cell and macrophage responsiveness. In parallel, Sema4D modulates angiogenesis and vascular remodeling, influences platelet aggregation and thrombus formation, and even governs bone remodeling by affecting osteoclast and osteoblast activity. These studies highlight its ability to trigger proteolytic shedding and to signal via receptors such as plexin‑B1 and CD72, thereby orchestrating processes ranging from inflammatory responses to tissue repair."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, additional investigations extend the impact of Sema4D signaling to the regulation of microglial activation, synapse development, and tissue‐specific remodeling events such as retinal phagocytosis, estrogen‐dependent epithelial apoptosis, and the control of osteoblast–osteoclast communication. Sema4D thereby emerges as a pivotal factor that, through mechanisms including proteolytic cleavage and receptor complex formation, modulates cell migration, proliferation, and programmed cell death in contexts as varied as neuroinflammation, tumor progression, and vascular as well as bone homeostasis. In the absence of any evidence about LINC00554 in these reports, the intricate regulatory circuitry governed by Sema4D may nonetheless serve as a conceptual framework for future studies exploring whether noncoding RNAs such as LINC00554 modulate similar signaling networks."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "32"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Atsushi Kumanogoh, Kazuhiro Suzuki, EweSeng Ch'ng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Requirement for the lymphocyte semaphorin, CD100, in the induction of antigen-specific T cells and the maturation of dendritic cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.169.3.1175"}], "href": "https://doi.org/10.4049/jimmunol.169.3.1175"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12133937"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12133937"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Silvia Giordano, Simona Corso, Paolo Conrotto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The semaphorin 4D receptor controls invasive growth by coupling with Met."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb843"}], "href": "https://doi.org/10.1038/ncb843"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12198496"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12198496"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Atsushi Kumanogoh, Satoko Marukawa, Kazuhiro Suzuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature01037"}], "href": "https://doi.org/10.1038/nature01037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12374982"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12374982"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Caroline Moreau-Fauvarque, Atsushi Kumanogoh, Emeline Camand, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The transmembrane semaphorin Sema4D/CD100, an inhibitor of axonal growth, is expressed on oligodendrocytes and upregulated after CNS lesion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2003)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14534257"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14534257"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kenta Masuda, Tatsuo Furuyama, Mizue Takahara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sema4D stimulates axonal outgrowth of embryonic DRG sensory neurones."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Cells (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2443.2004.00766.x"}], "href": "https://doi.org/10.1111/j.1365-2443.2004.00766.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15330859"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15330859"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ming Li, Kim M O'Sullivan, Lynelle K Jones, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CD100 enhances dendritic cell and CD4+ cell activation leading to pathogenetic humoral responses and immune complex glomerulonephritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.177.5.3406"}], "href": "https://doi.org/10.4049/jimmunol.177.5.3406"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16920982"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16920982"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "John R Basile, Kenn Holmbeck, Thomas H Bugge, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MT1-MMP controls tumor-induced angiogenesis through the release of semaphorin 4D."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M609570200"}], "href": "https://doi.org/10.1074/jbc.M609570200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17204469"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17204469"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Li Zhu, Wolfgang Bergmeier, Jie Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0606344104"}], "href": "https://doi.org/10.1073/pnas.0606344104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17244710"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17244710"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Avital Regev, Shlomit Goldman, Eliezer Shalev "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin-4D (Sema-4D), the Plexin-B1 ligand, is involved in mouse ovary follicular development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Biol Endocrinol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1477-7827-5-12"}], "href": "https://doi.org/10.1186/1477-7827-5-12"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17376242"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17376242"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Raimon Duran-Struuck, Isao Tawara, Kathi Lowler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel role for the semaphorin Sema4D in the induction of allo-responses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Blood Marrow Transplant (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbmt.2007.07.014"}], "href": "https://doi.org/10.1016/j.bbmt.2007.07.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17950916"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17950916"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jose Rafael Sierra, Simona Corso, Luisa Caione, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20072602"}], "href": "https://doi.org/10.1084/jem.20072602"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18559453"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18559453"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Alexander Korostylev, Thomas Worzfeld, Suhua Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A functional role for semaphorin 4D/plexin B1 interactions in epithelial branching morphogenesis during organogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.019760"}], "href": "https://doi.org/10.1242/dev.019760"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18799546"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18799546"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Marcia Toguchi, Daniel Gonzalez, Sohei Furukawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of Sema4D in the control of microglia activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurochem Int (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuint.2009.05.013"}], "href": "https://doi.org/10.1016/j.neuint.2009.05.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19467284"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19467284"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Kazunori Yukawa, Tetsuji Tanaka, Noriko Takeuchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sema4D/CD100 deficiency leads to superior performance in mouse motor behavior."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Can J Neurol Sci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1017/s0317167100007101"}], "href": "https://doi.org/10.1017/s0317167100007101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19534337"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19534337"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "A Hirschberg, S Deng, A Korostylev, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene deletion mutants reveal a role for semaphorin receptors of the plexin-B family in mechanisms underlying corticogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01458-09"}], "href": "https://doi.org/10.1128/MCB.01458-09"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19948886"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19948886"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Tatsusada Okuno, Yuji Nakatsuji, Masayuki Moriya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Roles of Sema4D-plexin-B1 interactions in the central nervous system for pathogenesis of experimental autoimmune encephalomyelitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.0903302"}], "href": "https://doi.org/10.4049/jimmunol.0903302"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20038643"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20038643"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Kenneth M Wannemacher, Li Zhu, Hong Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Diminished contact-dependent reinforcement of Syk activation underlies impaired thrombus growth in mice lacking Semaphorin 4D."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2010-04-279943"}], "href": "https://doi.org/10.1182/blood-2010-04-279943"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20855865"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20855865"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Takako Negishi-Koga, Masahiro Shinohara, Noriko Komatsu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Suppression of bone formation by osteoclastic expression of semaphorin 4D."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.2489"}], "href": "https://doi.org/10.1038/nm.2489"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22019888"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22019888"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Romain Dacquin, Chantal Domenget, Atsushi Kumanogoh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Control of bone resorption by semaphorin 4D is dependent on ovarian function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0026627"}], "href": "https://doi.org/10.1371/journal.pone.0026627"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22046317"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22046317"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Deborah A Witherden, Megumi Watanabe, Olivia Garijo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The CD100 receptor interacts with its plexin B2 ligand to regulate epidermal γδ T cell function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2012.05.026"}], "href": "https://doi.org/10.1016/j.immuni.2012.05.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22902232"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22902232"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "T F Meehan, D A Witherden, C-H Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protection against colitis by CD100-dependent modulation of intraepithelial γδ T lymphocyte function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mucosal Immunol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/mi.2013.32"}], "href": "https://doi.org/10.1038/mi.2013.32"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23695512"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23695512"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Takuji Ito, Tao Bai, Tetsuji Tanaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Estrogen-dependent proteolytic cleavage of semaphorin 4D and plexin-B1 enhances semaphorin 4D-induced apoptosis during postnatal vaginal remodeling in pubescent mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0097909"}], "href": "https://doi.org/10.1371/journal.pone.0097909"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24841081"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24841081"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Takenobu Wada, Toshinori Sawano, Takashi Tanaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Absence of Sema4D improves oligodendrocyte recovery after cerebral ischemia/reperfusion injury in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurosci Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neures.2015.12.016"}], "href": "https://doi.org/10.1016/j.neures.2015.12.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26752319"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26752319"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Keishi Otsu, Hiroko Ida-Yonemochi, Naoki Fujiwara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Semaphorin 4D-RhoA-Akt Signal Cascade Regulates Enamel Matrix Secretion in Coordination With Cell Polarization During Ameloblast Differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bone Miner Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jbmr.2876"}], "href": "https://doi.org/10.1002/jbmr.2876"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27218883"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27218883"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Masayuki Nishide, Satoshi Nojima, Daisuke Ito, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin 4D inhibits neutrophil activation and is involved in the pathogenesis of neutrophil-mediated autoimmune vasculitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Rheum Dis (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/annrheumdis-2016-210706"}], "href": "https://doi.org/10.1136/annrheumdis-2016-210706"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28416516"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28416516"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Toshinori Sawano, Ryo Tsuchihashi, Fumiya Watanabe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Changes in L-arginine metabolism by Sema4D deficiency induce promotion of microglial proliferation in ischemic cortex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroscience (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuroscience.2019.03.037"}], "href": "https://doi.org/10.1016/j.neuroscience.2019.03.037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30922994"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30922994"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Ryo Tsuchihashi, Toshinori Sawano, Fumiya Watanabe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of IFN-β induced by Sema4D-dependent partial Erk1/2 inhibition promotes NO production in microglia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.10.201"}], "href": "https://doi.org/10.1016/j.bbrc.2019.10.201"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31708102"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31708102"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Yilin Mao, Elizabeth E Evans, Vikas Mishra, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Anti-Semaphorin 4D Rescues Motor, Cognitive, and Respiratory Phenotypes in a Rett Syndrome Mouse Model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms22179465"}], "href": "https://doi.org/10.3390/ijms22179465"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34502373"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34502373"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Zhaoyichun Zhang, Lei Lu, Tao Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of Semaphorin 4D/Plexin-B1 signaling inhibits the subchondral bone loss in early-stage osteoarthritis of the temporomandibular joint."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Oral Biol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.archoralbio.2022.105365"}], "href": "https://doi.org/10.1016/j.archoralbio.2022.105365"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35151027"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35151027"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Zhuo Zhang, Duoli Zhang, Fang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sema4D silencing increases the sensitivity of nivolumab to B16-F10 resistant melanoma via inhibiting the PI3K/AKT signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.15172"}], "href": "https://doi.org/10.7717/peerj.15172"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37096066"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37096066"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Takenobu Ishii, Montserrat Ruiz-Torruella, Jae Young Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Soluble Sema4D cleaved from osteoclast precursors by TACE suppresses osteoblastogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.17416"}], "href": "https://doi.org/10.1111/jcmm.17416"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37170687"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37170687"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Lifu Wang, Dinghao Li, Zifeng Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockout of Sema4D alleviates liver fibrosis by suppressing AOX1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacol Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.phrs.2023.106886"}], "href": "https://doi.org/10.1016/j.phrs.2023.106886"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37591326"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37591326"}]}]}]}