{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In a study investigating prognostic biomarkers for hepatocellular carcinoma (HCC), LINC00556 was identified as one of four long noncoding RNAs (lncRNAs) that together form a signature capable of stratifying HCC patients into distinct prognostic groups. The analysis, conducted on a training set of 90 patients and validated on an independent set, revealed that the four‐lncRNA signature—including LINC00556—was significantly associated with overall survival. Patients classified into different risk groups exhibited markedly different median survival times, and multivariate Cox analysis confirmed that this lncRNA signature served as an independent predictor of HCC prognosis. Although LINC00556’s precise biological mechanisms were not elucidated in the study, its inclusion in the prognostic model underscores its potential clinical utility as a biomarker for assessing patient risk."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Haitao Jiang, Lianhe Zhao, Yunjie Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A four-long noncoding RNA signature predicts survival of hepatocellular carcinoma patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.23377"}], "href": "https://doi.org/10.1002/jcla.23377"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32474975"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32474975"}]}]}]}