LINC00577 Gene

Name long intergenic non-protein coding RNA 577
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have revealed that the long non‐coding RNA LIN28B‐AS1, a cancer‐testis (CT) gene product normally restricted to the testis, plays multifaceted roles in human malignancies and inflammatory responses. In lung adenocarcinoma, LIN28B‐AS1 functions as a cis‐regulator that enhances the stability of LIN28B messenger RNA through direct binding to the CT‐associated RNA‐binding protein IGF2BP1, thereby promoting cell proliferation, metastasis, cell cycle progression, DNA damage repair, and genome instability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In hepatocellular carcinoma, LIN28B‐AS1 similarly interacts with IGF2BP1 to upregulate critical oncogenic transcripts—including IGF2, Gli1, and Myc—thus accelerating tumor growth, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Furthermore, in human macrophages, LIN28B‐AS1 is required for lipopolysaccharide‐induced NFκB activation; by facilitating the association between IGF2BP1 and key NFκB components, it drives the expression and production of pro‐inflammatory cytokines such as IL‐1β, IL‐6, and TNF‐α."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Collectively, these findings underscore a pivotal role for LIN28B‐AS1 in modulating oncogenic and inflammatory pathways via its direct interactions with IGF2BP1, suggesting that the LIN28B‐AS1/IGF2BP1 axis may represent a promising target for therapeutic intervention.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Cheng Wang, Yayun Gu, Erbao Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A cancer-testis non-coding RNA LIN28B-AS1 activates driver gene LIN28B by interacting with IGF2BP1 in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-018-0548-x"}], "href": "https://doi.org/10.1038/s41388-018-0548-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30353165"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30353165"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jian Zhang, Kewei Hu, Yong-Qiang Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LIN28B-AS1-IGF2BP1 binding promotes hepatocellular carcinoma cell progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-02967-z"}], "href": "https://doi.org/10.1038/s41419-020-02967-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32917856"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32917856"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zichen Xie, Heng Zhang, Jiqin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LIN28B-AS1-IGF2BP1 association is required for LPS-induced NFκB activation and pro-inflammatory responses in human macrophages and monocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.09.012"}], "href": "https://doi.org/10.1016/j.bbrc.2019.09.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31537384"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31537384"}]}]}]}
Synonyms LIN28B-AS1, DJ439I14.1, C6ORF220
NCBI Gene ID 100113403
API
Download Associations
Predicted Functions View LINC00577's ARCHS4 Predicted Functions.
Co-expressed Genes View LINC00577's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View LINC00577's ARCHS4 Predicted Functions.

Functional Associations

LINC00577 has 177 functional associations with biological entities spanning 4 categories (disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 10 datasets.

Click the + buttons to view associations for LINC00577 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00577 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00577 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
DISEASES Experimental Gene-Disease Association Evidence Scores diseases associated with LINC00577 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores diseases co-occuring with LINC00577 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of LINC00577 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of LINC00577 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00577 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of LINC00577 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of LINC00577 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores tissues co-occuring with LINC00577 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.