{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Across several studies investigating various cancer types, LINC00578 has emerged as a long non‐coding RNA with significant clinical and functional implications. In lung adenocarcinoma, LINC00578 was found to be markedly upregulated in tumor tissues where its increased expression was strongly associated with the presence of metastasis and poorer patient survival. Moreover, in an analysis of copy number alterations, LINC00578 amplification correlated with improved overall survival, suggesting that its dosage effects may have a complex, context‐dependent role in tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In pancreatic cancer, high levels of LINC00578 were observed in both tissue and serum samples, and elevated expression was correlated with more advanced clinical stages and reduced survival rates. Functional experiments demonstrated that silencing LINC00578 inhibited pancreatic cancer cell proliferation, suggesting a pro‐tumorigenic (oncogenic) role for this lncRNA in this context."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Additionally, LINC00578 has been incorporated into prognostic risk models for breast cancer. Within signatures associated with autophagy, immune response, and cancer stem cell characteristics, its expression contributes to stratifying patients according to risk, thereby highlighting its potential as a biomarker and therapeutic target. Although the exact molecular mechanisms remain to be fully elucidated, its consistent inclusion in multiple prognostic panels underscores its clinical relevance across tumor types."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Bing Zhao, Hang Xu, Xiaoye Ai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression profiles of long noncoding RNAs in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S167633"}], "href": "https://doi.org/10.2147/OTT.S167633"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30233202"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30233202"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Li Wang, Hongying Zhao, Yingqi Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Systematic identification of lincRNA-based prognostic biomarkers by integrating lincRNA expression and copy number variation in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.31865"}], "href": "https://doi.org/10.1002/ijc.31865"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30226269"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30226269"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Baogang Zhang, Changfeng Li, Zhixia Sun "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC00346, LINC00578, LINC00673, LINC00671, LINC00261, and SNHG9 are novel prognostic markers for pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Transl Res (2018)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30210701"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30210701"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiaoying Li, Feng Jin, Yang Li "}, {"type": "b", "children": [{"type": "t", "text": "A novel autophagy-related lncRNA prognostic risk model for breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.15980"}], "href": "https://doi.org/10.1111/jcmm.15980"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33216456"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33216456"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Wei Ma, Fangkun Zhao, Xinmiao Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Immune-related lncRNAs as predictors of survival in breast cancer: a prognostic signature."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-020-02522-6"}], "href": "https://doi.org/10.1186/s12967-020-02522-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33225954"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33225954"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xiaoying Li, Yang Li, Xinmiao Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and validation of stemness-related lncRNA prognostic signature for breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-020-02497-4"}], "href": "https://doi.org/10.1186/s12967-020-02497-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32867770"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32867770"}]}]}]}