{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Although none of the three studies explicitly focused on LINC00583, they provide context for understanding how long non‐coding RNAs (lncRNAs) – the family to which LINC00583 belongs – may contribute to the regulation of complex traits and diseases. In one study investigating frailty in older adults, variation in the 9p21–23 region was associated with increased risk of frailty, a finding that raises the possibility that lncRNAs in this genomic hotspot could modulate age‐related processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, an extensive genome‐wide association analysis of plasma levels of coagulation factors implicated regulatory elements in the modulation of key hemostatic proteins, suggesting that non-coding transcripts might influence thrombotic risk through effects on endothelial function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Finally, a large integrative eQTL study across multiple cancer types highlighted how ncRNAs can be linked to cancer-related traits and patient survival, reinforcing the concept that lncRNAs serve as important regulatory molecules in human disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " \n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n By extrapolation, the function of LINC00583 – as a member of the lncRNA family – may involve modulation of gene expression networks that contribute to aging phenotypes, hemostatic balance, and cancer biology. Further focused experiments are needed to define its precise mechanistic roles in these complex biological processes.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sanish Sathyan, Nir Barzilai, Gil Atzmon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic Insights Into Frailty: Association of 9p21-23 Locus With Frailty."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Med (Lausanne) (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fmed.2018.00105"}], "href": "https://doi.org/10.3389/fmed.2018.00105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29765957"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29765957"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Maria Sabater-Lleal, Jennifer E Huffman, Paul S de Vries, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-Wide Association Transethnic Meta-Analyses Identifies Novel Associations Regulating Coagulation Factor VIII and von Willebrand Factor Plasma Levels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCULATIONAHA.118.034532"}], "href": "https://doi.org/10.1161/CIRCULATIONAHA.118.034532"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30586737"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30586737"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jiang Li, Yawen Xue, Muhammad Talal Amin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ncRNA-eQTL: a database to systematically evaluate the effects of SNPs on non-coding RNA expression across cancer types."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkz711"}], "href": "https://doi.org/10.1093/nar/gkz711"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31410488"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31410488"}]}]}]}