LINC00588 Gene

Name long intergenic non-protein coding RNA 588
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Abnormal X‐chromosome dosage, as observed in Turner (45,X) and Klinefelter (47,XXY) syndromes, causes widespread epigenetic alterations on autosomal loci, highlighting the importance of methylation regulation in human disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In a separate study focusing on osteosarcoma, the long non‐coding RNA LINC00588 was found to be aberrantly expressed – being downregulated in primary bone tumors and upregulated in lung metastatic lesions. Functional assays demonstrated that overexpression of LINC00588 suppresses cell proliferation, viability, migration, invasion, epithelial‐to‐mesenchymal transition, and tumor growth, whereas its knockdown produces the opposite effect. Mechanistically, LINC00588 appears to exert its tumor‐suppressive role by binding to and downregulating miRNA‑1972, which in turn modulates TP53 at the protein level. Collectively, these findings suggest that the LINC00588/miRNA‑1972/TP53 axis may serve as a potential therapeutic target and diagnostic biomarker in osteosarcoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Amit Sharma, Muhammad Ahmer Jamil, Nicole Nuesgen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNA methylation signature in peripheral blood reveals distinct characteristics of human X chromosome numerical aberrations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Epigenetics (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13148-015-0112-2"}], "href": "https://doi.org/10.1186/s13148-015-0112-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26221191"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26221191"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Fu-Chao Zhou, Yue-Hui Zhang, Hai-Tao Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LINC00588 Suppresses the Progression of Osteosarcoma by Acting as a ceRNA for miRNA-1972."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Pharmacol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fphar.2020.00255"}], "href": "https://doi.org/10.3389/fphar.2020.00255"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32265694"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32265694"}]}]}]}
Synonyms C8ORF71
Proteins CH071_HUMAN
NCBI Gene ID 26138
API
Download Associations
Predicted Functions View LINC00588's ARCHS4 Predicted Functions.
Co-expressed Genes View LINC00588's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View LINC00588's ARCHS4 Predicted Functions.

Functional Associations

LINC00588 has 1,007 functional associations with biological entities spanning 7 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 27 datasets.

Click the + buttons to view associations for LINC00588 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray tissue samples with high or low expression of LINC00588 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles tissues with high or low expression of LINC00588 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
BioGPS Cell Line Gene Expression Profiles cell lines with high or low expression of LINC00588 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
BioGPS Human Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of LINC00588 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00588 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of LINC00588 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of LINC00588 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of LINC00588 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of LINC00588 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00588 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
DISEASES Experimental Gene-Disease Association Evidence Scores diseases associated with LINC00588 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at LINC00588 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of LINC00588 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of LINC00588 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing LINC00588 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of LINC00588 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of LINC00588 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of LINC00588 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of LINC00588 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of LINC00588 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of LINC00588 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00588 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures small molecule perturbations changing expression of LINC00588 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
MSigDB Cancer Gene Co-expression Modules co-expressed genes for LINC00588 from the MSigDB Cancer Gene Co-expression Modules dataset.
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations gene perturbations changing expression of LINC00588 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at LINC00588 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of LINC00588 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.