{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNA LINC00592 has recently emerged as a potential cancer‐related molecule with roles in both prognosis and tumor progression. In a study on gastric cancer patients, LINC00592 was identified as one of thirteen prognostic lncRNA biomarkers that, when combined into a signature, robustly predicted disease‐free survival, facilitating noninvasive preoperative risk stratification (1). In cervical cancer, LINC00592 was uniquely found to be differentially expressed among lncRNAs located in differentially methylated regions. Its expression was highly correlated with several transcriptional regulators, including ZNF20, ZNF441, ZNF573, and TMF1, and it appears capable of binding microRNAs associated with tumor progression, suggesting that LINC00592 may act through the regulation of transcription and maintenance of structural integrity to activate cancer progression (2). Collectively, these findings suggest that LINC00592 not only serves as a prognostic biomarker in the context of gastric cancer but may also play a critical role in transcriptional regulatory mechanisms driving tumorigenesis in cervical cancer.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Citations:."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Canchang Cheng, Qicai Wang, Minggu Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrated analysis reveals potential long non-coding RNA biomarkers and their potential biological functions for disease free survival in gastric cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-019-0846-6"}], "href": "https://doi.org/10.1186/s12935-019-0846-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31080364"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31080364"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Li-Yun Yuan, Xiaomin Qin, Lin Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The transcriptome profiles and methylation status revealed the potential cancer-related lncRNAs in patients with cervical cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.27661"}], "href": "https://doi.org/10.1002/jcp.27661"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30362566"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30362566"}]}]}]}