{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00593 has emerged as a potentially valuable prognostic long non‐coding RNA in cancer. In a study of localized prostate cancer, a signature comprising multiple dysregulated lncRNAs was found to be significantly associated with biochemical recurrence–free survival. Although the prostate cancer report did not individually characterize LINC00593, its inclusion in the multi‐lncRNA prognostic signature implies that its aberrant expression may contribute to patient risk stratification."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in the context of triple‐negative breast cancer, LINC00593 was identified as one of 10 independent prognostic m6A‐related lncRNAs. In this study, expression differences of LINC00593 correlated with high-risk disease, and functional analyses using a competing endogenous RNA network suggested that it might regulate pathways involved in cell communication, signal transduction, and other cancer-related processes. These observations indicate that dysregulation of LINC00593 is associated with a poorer overall survival profile in TNBC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Collectively, the findings support a prognostic role for LINC00593 across different cancer types, underscoring its potential utility as a biomarker and as a regulator of key oncogenic pathways.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jinyuan Xu, Yujia Lan, Fulong Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptome analysis reveals a long non-coding RNA signature to improve biochemical recurrence prediction in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.25048"}], "href": "https://doi.org/10.18632/oncotarget.25048"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29861844"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29861844"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jie Wu, Yan Cai, Gaiping Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A ten N6-methyladenosine-related long non-coding RNAs signature predicts prognosis of triple-negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.23779"}], "href": "https://doi.org/10.1002/jcla.23779"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33934391"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33934391"}]}]}]}