{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long intergenic non‐coding RNA LINC00595 has been identified as a stimulus‐specific immunomodulatory factor in monocytes during fungal infections. In particular, exposure to fungal pathogens such as "}, {"type": "i", "children": [{"type": "t", "text": "Candida albicans"}]}, {"type": "t", "text": " and "}, {"type": "i", "children": [{"type": "t", "text": "Aspergillus fumigatus"}]}, {"type": "t", "text": " triggers massive fold changes in LINC00595 expression, suggesting that it may serve as an early biomarker of infection and a potential therapeutic target through its regulation of chemokine and cytokine signaling, a process that is further modulated by vitamins A and D."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although other studies have explored dysregulation of long non‑coding RNAs in diverse pathological settings – for example, the involvement of non‐coding RNAs in ceRNA networks related to autophagy regulation in pancreatic cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "and the dysregulated expression profile of lncRNAs associated with tumorigenesis in thyroid cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "– LINC00595 emerges as a promising candidate specifically in the context of immunomodulatory responses during fungal infections.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Konstantin Riege, Martin Hölzer, Tilman E Klassert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Massive Effect on LncRNAs in Human Monocytes During Fungal and Bacterial Infections and in Response to Vitamins A and D."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep40598"}], "href": "https://doi.org/10.1038/srep40598"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28094339"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28094339"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Dan-Ming Wei, Meng-Tong Jiang, Peng Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Potential ceRNA networks involved in autophagy suppression of pancreatic cancer caused by chloroquine diphosphate: A study based on differentially‑expressed circRNAs, lncRNAs, miRNAs and mRNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2018.4660"}], "href": "https://doi.org/10.3892/ijo.2018.4660"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30570107"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30570107"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wei Lu, Yongcan Xu, Jiewei Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of differential expressed lncRNAs in human thyroid cancer by a genome-wide analyses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.1627"}], "href": "https://doi.org/10.1002/cam4.1627"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29923329"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29923329"}]}]}]}