{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Although the study by itself (1) does not provide a direct functional characterization of LINC00596, its identification among the genetic regions linked to the mucinous tumor phenotype in colorectal cancer suggests that LINC00596, a long noncoding RNA, may be involved in the regulation of gene expression that contributes to this aggressive tumor subtype. In this context, genetic variants in regions that potentially include LINC00596 were associated with significant improvements in discriminating mucinous tumors from non‐mucinous ones, implying that LINC00596 could play a role in modulating the molecular pathways underlying mucinous histology. However, further investigations are needed to elucidate the precise mechanisms by which LINC00596 influences colorectal cancer pathogenesis and to determine whether it might serve as a useful biomarker or therapeutic target."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Michelle E Penney, Patrick S Parfrey, Sevtap Savas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Associations of single nucleotide polymorphisms with mucinous colorectal cancer: genome-wide common variant and gene-based rare variant analyses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomark Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s40364-018-0133-z"}], "href": "https://doi.org/10.1186/s40364-018-0133-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29942513"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29942513"}]}]}]}