{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long intergenic noncoding RNA 00598 (LINC00598) has been implicated in diverse regulatory functions relating to cell cycle control and cancer pathogenesis. In one study, LINC00598 was demonstrated to modulate the transcription of CCND2 by influencing the transcriptional regulatory activity of FoxO1 at the CCND2 promoter, with its knockdown leading to G0/G1 cell cycle arrest and reduced cell proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In another investigation focused on colon cancer, LINC00598 was identified as part of an immune-related long noncoding RNA pair that contributed to a prognostic signature, suggesting that its expression may serve as a biomarker for adverse survival outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Furthermore, integrated bioinformatics analysis of pituitary prolactinoma highlighted LINC00598 as a hub gene in both target gene–miRNA and target gene–transcription factor regulatory networks, implying a potential role in the molecular mechanisms driving tumor initiation and progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Oh-Seok Jeong, Yun-Cheol Chae, Hyeonsoo Jung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA linc00598 regulates CCND2 transcription and modulates the G1 checkpoint."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep32172"}], "href": "https://doi.org/10.1038/srep32172"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27572135"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27572135"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Minxian Xu, Qing Li, Jianfang Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Immune-Related lncRNA Pairs and Construction and Validation of a New Prognostic Signature of Colon Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Can J Gastroenterol Hepatol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/5827544"}], "href": "https://doi.org/10.1155/2022/5827544"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35399646"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35399646"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Vikrant Ghatnatti, Basavaraj Vastrad, Swetha Patil, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of potential and novel target genes in pituitary prolactinoma by bioinformatics analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "AIMS Neurosci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3934/Neuroscience.2021014"}], "href": "https://doi.org/10.3934/Neuroscience.2021014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33709028"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33709028"}]}]}]}