{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00599—also known as retinal non‐coding RNA3 (RNCR3)—has emerged as a multifunctional long non‐coding RNA that modulates cellular homeostasis in both the nervous and vascular systems. In the context of neural malignancies, studies have reported that dysregulation of LINC00599 is associated with brain tumor progression. For instance, in glioma, elevated LINC00599 expression correlates with increased proliferation, invasiveness, and poorer patient outcomes, and mechanistic investigations suggest that LINC00599 functions as a competing endogenous RNA (ceRNA) by sponging microRNAs such as miR‑185‑5p. This, in turn, influences downstream effectors like PAK7, an important regulator of axon guidance and tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " \n Although other reports in glioblastoma models indicate that increasing LINC00599 may suppress cell survival and induce apoptosis—pointing to context‐dependent roles in tumor biology"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "—the overall evidence highlights its involvement in regulating ceRNA networks that affect key signaling pathways linked to neural cell fate and proliferation.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond cancer, genetic variations in LINC00599 have been implicated in non-neoplastic conditions. Polymorphism analyses have revealed significant associations between LINC00599 variants and susceptibility to hypoxia‐related disorders, such as high‐altitude pulmonary edema (HAPE)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", and with steroid-induced osteonecrosis of the femoral head (ONFH)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " These findings suggest that LINC00599 may contribute to pathogenesis by influencing cellular stress responses and tissue remodeling.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, current studies support a model in which LINC00599 acts as a regulatory hub—a ceRNA that modulates microRNA activity to fine-tune the expression of genes involved in axon guidance, cell proliferation, and apoptosis. Its dysregulation appears to promote neural tumor progression in certain contexts while genetic variability in LINC00599 is linked to vascular and musculoskeletal disorders. Thus, LINC00599 presents as a potential biomarker and therapeutic target in diseases ranging from glioma to hypoxia-related and steroid-induced conditions.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xuefeng Wang, Shuang Liu, Zhengkai Shao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bioinformatic analysis of the potential molecular mechanism of PAK7 expression in glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2020.11206"}], "href": "https://doi.org/10.3892/mmr.2020.11206"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32626960"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32626960"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Bing Zhu, Shenyan Zhang, Ning Meng, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA-RNCR3 overexpression deleteriously affects the growth of glioblastoma cells through miR-185-5p/Krüppel-like factor 16 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.27167"}], "href": "https://doi.org/10.1002/jcb.27167"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29953649"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29953649"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xue He, Jianwen Zheng, Yongjun He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Non-coding RNA LINC-PINT and LINC00599 Polymorphisms are Associated With High-altitude Pulmonary Edema in Chinese."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Bronconeumol (Engl Ed) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.arbres.2019.09.021"}], "href": "https://doi.org/10.1016/j.arbres.2019.09.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31761491"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31761491"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Menghu Sun, Yuju Cao, Tiantian Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between LINC-PINT and LINC00599 gene polymorphism and the risk of steroid-induced osteonecrosis of the femoral head in the population of northern China."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Steroids (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.steroids.2021.108886"}], "href": "https://doi.org/10.1016/j.steroids.2021.108886"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34245766"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34245766"}]}]}]}