{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00601 appears to function as an oncogenic long non‐coding RNA in multiple cancer types. In hepatocellular carcinoma (HCC), LINC00601 is markedly upregulated in tumor tissues and cell lines. Functional studies have demonstrated that its elevated expression promotes HCC cell proliferation, facilitates cell cycle progression, and suppresses apoptosis. Mechanistically, LINC00601 enhances tumor development by activating the mitogen‐activated protein kinase (MAPK) signaling pathway, as evidenced by decreased phosphorylation levels of key MAPK components (p-P38 and p-ERK) upon LINC00601 knockdown."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Additionally, integrated transcriptomic analyses in esophageal squamous cell carcinoma (ESCC) have incorporated LINC00601 into multi-RNA prognostic models. These studies suggest that LINC00601, alongside other non-coding and coding RNAs, may play a critical role in the regulatory networks that determine clinical outcomes in ESCC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Overall, the collective findings indicate that LINC00601 contributes to tumor progression by modulating pivotal signaling pathways and cellular behaviors, thereby emerging as both a potential prognostic biomarker and a promising therapeutic target in cancers such as HCC and ESCC."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Y-C Wang, B-H Hu, W-W Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Linc00601 upregulation promotes hepatocellular carcinoma development by activating MAPK signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202006_21498"}], "href": "https://doi.org/10.26355/eurrev_202006_21498"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32572918"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32572918"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaobo Shi, You Li, Yuchen Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide analysis of lncRNAs, miRNAs, and mRNAs forming a prognostic scoring system in esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.8368"}], "href": "https://doi.org/10.7717/peerj.8368"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32095316"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32095316"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yikang He, Yangfan Ye, Wei Tian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Novel lncRNA Panel Related to Ferroptosis, Tumor Progression, and Microenvironment is a Robust Prognostic Indicator for Glioma Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Cell Dev Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fcell.2021.788451"}], "href": "https://doi.org/10.3389/fcell.2021.788451"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34950662"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34950662"}]}]}]}