{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In a recent epigenome‐wide analysis assessing cord blood DNA, LINC00602 was identified among the top gene loci annotated to differentially methylated regions (DMRs) associated with childhood lung function. The study found that altered methylation at these regions, including those linked to LINC00602, correlates with respiratory outcomes such as reduced forced expiratory volume and an increased risk of developing childhood asthma as well as chronic obstructive pulmonary disease in adulthood."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although the precise molecular mechanisms underpinning LINC00602’s function remain to be fully defined, its epigenetic status in the neonatal period suggests a regulatory role that may influence key gene networks responsible for lung development and airway integrity. In this way, modifications at the LINC00602 locus could contribute to altered transcriptional programs that predispose individuals to impaired lung function and respiratory disease across the life course."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Herman T den Dekker, Kimberley Burrows, Janine F Felix, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Newborn DNA-methylation, childhood lung function, and the risks of asthma and COPD across the life course."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Respir J (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1183/13993003.01795-2018"}], "href": "https://doi.org/10.1183/13993003.01795-2018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30765504"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30765504"}]}]}]}