{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent genomic studies have provided insights into the role of long non‐coding RNA LINC00603 in cancer. While a comprehensive genome‐wide analysis in colorectal cancer identified multiple novel risk signals—none of which directly implicated LINC00603—in a large cohort study"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", a separate investigation into lung cancer demonstrated that smoking is associated with specific lncRNA alterations. In particular, in male lung adenocarcinoma patients, alterations in LINC00603 showed a positive correlation with the smoking index."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " This observation suggests that LINC00603 may act as a smoking-responsive regulatory RNA that contributes to lung tumorigenesis in a gender-dependent manner. Further studies are warranted to elucidate the precise molecular mechanisms by which LINC00603 influences smoking-related lung cancer development.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jeroen R Huyghe, Stephanie A Bien, Tabitha A Harrison, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Discovery of common and rare genetic risk variants for colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41588-018-0286-6"}], "href": "https://doi.org/10.1038/s41588-018-0286-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30510241"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30510241"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Bing Liu, Yuan Liu, Jingfeng Zou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Smoking is Associated with Lung Adenocarcinoma and Lung Squamous Cell Carcinoma Progression through Inducing Distinguishing lncRNA Alterations in Different Genders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Agents Med Chem (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/1871520621666210727115147"}], "href": "https://doi.org/10.2174/1871520621666210727115147"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34315392"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34315392"}]}]}]}