{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long noncoding RNA (lncRNA) LINC00607 has emerged as a context‐dependent regulator in several disease settings. In lung adenocarcinoma, for example, LINC00607 is one of the most significantly downregulated lncRNAs in tumor tissues compared with adjacent normal tissues, although its direct correlation with clinicopathological features remains to be fully elucidated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In thyroid cancer, LINC00607 is up‑regulated in doxorubicin‑resistant cell lines and tumor tissues, where it promotes drug resistance and cell survival by repressing apoptosis; this is achieved through the downregulation of CASP9 via enhanced promoter methylation, a process that correlates with poorer patient prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, in hepatocellular carcinoma LINC00607 is part of an eight‑lncRNA prognostic signature that is closely associated with tumor mutation burden and immune cell infiltration, underscoring its potential utility as a prognostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Finally, under conditions of diabetic stress in endothelial cells, LINC00607 contributes to the formation of RNA–chromatin interactions at super enhancers, and its suppression attenuates the expression of SERPINE1 – a key pro‐inflammatory and pro‐fibrotic gene – thereby modulating endothelial dysfunction."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings suggest that LINC00607 exerts its effects through transcriptional and epigenetic regulatory mechanisms, influencing cellular processes such as apoptosis, drug resistance, and inflammatory gene expression. As such, LINC00607 represents a promising molecular target with potential applications in cancer prognostication and the modulation of disease‐related cellular dysfunction.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Bing Zhao, Hang Xu, Xiaoye Ai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression profiles of long noncoding RNAs in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S167633"}], "href": "https://doi.org/10.2147/OTT.S167633"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30233202"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30233202"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lanzhen Li, Zhongcheng Gao, Lei Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC00607 silencing exerts antioncogenic effects on thyroid cancer through the CASP9 Promoter methylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.16265"}], "href": "https://doi.org/10.1111/jcmm.16265"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34232553"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34232553"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Feng Qi, Xiaojing Du, Zhiying Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor Mutation Burden-Associated LINC00638/miR-4732-3p/ULBP1 Axis Promotes Immune Escape "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "via"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " PD-L1 in Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2021.729340"}], "href": "https://doi.org/10.3389/fonc.2021.729340"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34568062"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34568062"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Riccardo Calandrelli, Lixia Xu, Yingjun Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stress-induced RNA-chromatin interactions promote endothelial dysfunction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-020-18957-w"}], "href": "https://doi.org/10.1038/s41467-020-18957-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33060583"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33060583"}]}]}]}