{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00609 displays context‐dependent roles in human disease. In lung cancer, for example, data derived from The Cancer Genome Atlas indicate that smoking is associated with multiple long non‐coding RNA alterations. In female lung adenocarcinoma patients, the smoking index is negatively correlated with LINC00609 expression, suggesting that decreased expression of LINC00609 may be linked to smoking‐induced molecular changes in this cancer type."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, in glioblastoma, LINC00609 is one component of an epithelial–mesenchymal transition (EMT)–related prognostic signature that is upregulated and associated with metastasis‐ and immune response–related pathways; its inclusion in this signature implies a potential role in tumor aggressiveness and poor patient prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Although no direct association of LINC00609 was reported in the context of oligodendrocyte pathology and neurodegeneration in multiple sclerosis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", these findings together underscore that LINC00609 may function in a disease‐ and tissue‐specific manner, potentially acting as a biomarker and modulator of cellular states in cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Bing Liu, Yuan Liu, Jingfeng Zou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Smoking is Associated with Lung Adenocarcinoma and Lung Squamous Cell Carcinoma Progression through Inducing Distinguishing lncRNA Alterations in Different Genders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Agents Med Chem (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/1871520621666210727115147"}], "href": "https://doi.org/10.2174/1871520621666210727115147"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34315392"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34315392"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "XinJie Yang, Sha Niu, JiaQiang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of an epithelial-mesenchymal transition-related lncRNA prognostic signature for patients with glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-03213-y"}], "href": "https://doi.org/10.1038/s41598-021-03213-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34880375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34880375"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sarah Jäkel, Eneritz Agirre, Ana Mendanha Falcão, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered human oligodendrocyte heterogeneity in multiple sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41586-019-0903-2"}], "href": "https://doi.org/10.1038/s41586-019-0903-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30747918"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30747918"}]}]}]}