{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00612 is emerging as a context‐dependent regulator in human disease. In bladder cancer, LINC00612 is upregulated and functions as a competing endogenous RNA (ceRNA) that sponges miR‑590, thereby upregulating PHF14. This regulation promotes epithelial–mesenchymal transition (EMT) and enhances cellular proliferation and invasion, positioning LINC00612 as a potential biomarker and therapeutic target for the disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In osteosarcoma, elevated expression of LINC00612 similarly promotes tumor progression by functioning as a ceRNA against miR‑214‑5p, which results in the upregulation of SOX4. This axis contributes to increased cell proliferation, invasion, and EMT, underscoring the role of LINC00612 in the aggressive behavior and metastatic potential of osteosarcoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In contrast, studies in chronic obstructive pulmonary disease (COPD) have revealed that LINC00612 is downregulated in lung tissues. Upregulation of LINC00612 in cigarette smoke extract–exposed human pulmonary microvascular endothelial cells was shown to alleviate apoptosis, inflammation, and oxidative stress through modulation of the miR‑31‑5p/Notch1 signaling pathway. These protective effects suggest that restoring LINC00612 levels could serve as a novel therapeutic strategy in COPD."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings highlight the multifaceted role of LINC00612 in regulating EMT, cell proliferation, invasion, and stress responses across different pathologies, and they support its further exploration as a potential target for therapeutic intervention in both cancers and COPD."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Liying Miao, Hong Yue Liu, Cuixing Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00612 enhances the proliferation and invasion ability of bladder cancer cells as ceRNA by sponging miR-590 to elevate expression of PHF14."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-019-1149-4"}], "href": "https://doi.org/10.1186/s13046-019-1149-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30940184"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30940184"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yuelai Zhou, Xiaolei Li, Huilin Yang "}, {"type": "b", "children": [{"type": "t", "text": "LINC00612 functions as a ceRNA for miR-214-5p to promote the proliferation and invasion of osteosarcoma in vitro and in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2020.112012"}], "href": "https://doi.org/10.1016/j.yexcr.2020.112012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32311343"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32311343"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jun Luo, Li Li, Die Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00612/miR-31-5p/Notch1 Axis Regulates Apoptosis, Inflammation, and Oxidative Stress in Human Pulmonary Microvascular Endothelial Cells Induced by Cigarette Smoke Extract."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Chron Obstruct Pulmon Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/COPD.S255696"}], "href": "https://doi.org/10.2147/COPD.S255696"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32921999"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32921999"}]}]}]}