{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00616 is one of a set of long non‐coding RNAs that have been identified as consistently differentially expressed in human germ cells, suggesting a potential regulatory role in spermatogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Its altered expression pattern, discovered through comparative analyses of multiple RNA‐seq studies on various germ cell populations, implicates LINC00616 in the modulation of key genes involved in processes such as cell proliferation, differentiation, and cell cycle regulation. Although the precise mechanistic function of LINC00616 remains to be fully elucidated, its association with potential targets—including genes related to centromere function, cytoskeletal organization, and cell cycle checkpoints—highlights its promise as a candidate for further investigation into its contribution to the regulation of spermatogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Meghali Joshi, Singh Rajender "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNAs (lncRNAs) in spermatogenesis and male infertility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Biol Endocrinol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12958-020-00660-6"}], "href": "https://doi.org/10.1186/s12958-020-00660-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33126901"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33126901"}]}]}]}