{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have revealed multifaceted roles for the long non‐coding RNA LINC00618 in cancer. In glioblastoma multiforme, LINC00618 was identified as a component of a prognostic PCG‐lncRNA signature that robustly stratifies postoperative patients into distinct risk groups with significantly different survival outcomes and responses to temozolomide‐chemoradiation, outperforming traditional clinical and molecular predictors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In human leukemia, LINC00618—a nuclear lncRNA that is typically downregulated—becomes strongly upregulated in response to vincristine treatment. Its elevated expression promotes apoptosis by increasing levels of pro‐apoptotic proteins such as BAX and enhancing caspase-3 cleavage. Moreover, LINC00618 accelerates ferroptosis by elevating lipid reactive oxygen species and iron levels while concurrently decreasing the expression of SLC7A11, a key regulator of cellular antioxidant defenses. Mechanistically, LINC00618 attenuates the expression of lymphoid-specific helicase (LSH), which is otherwise involved in enhancing SLC7A11 transcription, thereby linking the lncRNA’s function to crosstalk between apoptosis and ferroptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wei-Zhen Gao, Lie-Mei Guo, Tian-Qi Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a multidimensional transcriptome signature for survival prediction of postoperative glioblastoma multiforme patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-018-1744-8"}], "href": "https://doi.org/10.1186/s12967-018-1744-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30572911"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30572911"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zuli Wang, Xiaowen Chen, Na Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Nuclear Long Non-Coding RNA LINC00618 Accelerates Ferroptosis in a Manner Dependent upon Apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Ther (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymthe.2020.09.024"}], "href": "https://doi.org/10.1016/j.ymthe.2020.09.024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33002417"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33002417"}]}]}]}