{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The long intergenic noncoding RNA (lincRNA) LINC00619 has been shown to modulate key cellular processes across distinct pathological conditions. In gastric cancer, LINC00619 functions as a tumor suppressor by acting as a molecular sponge for miR‐224‑5p. By binding miR‑224‑5p, LINC00619 alleviates the microRNA’s inhibitory effect on the tumor suppressor OPCML, leading to reduced cell proliferation, migration, invasion, and enhanced apoptosis. These molecular events collectively contribute to diminished tumorigenicity in gastric cancer cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In osteosarcoma, LINC00619 has been demonstrated to inhibit tumor progression through a distinct mechanism involving the hepatocyte growth factor (HGF) and the PI3K-Akt signaling pathway. Here, LINC00619 directly targets HGF, resulting in the downregulation of the PI3K-Akt cascade, which in turn decreases the expression of proliferative and anti-apoptotic proteins while suppressing the migration and invasion capacities of osteosarcoma cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, preliminary findings from gene expression profiling in Hirschsprung's disease have identified LINC00619 among the differentially expressed genes implicated in the development of this congenital disorder. Although its precise mechanistic role in the pathogenesis of Hirschsprung's disease remains to be fully characterized, these data suggest a potential regulatory involvement of LINC00619 in neural crest-derived cell development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaohe Fang, Yong Dong, Ruilin Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00619 restricts gastric cancer progression by preventing microRNA-224-5p-mediated inhibition of OPCML."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Biochem Biophys (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.abb.2020.108390"}], "href": "https://doi.org/10.1016/j.abb.2020.108390"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32359894"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32359894"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xin Zi, Guoqiang Zhang, Shichao Qiu "}, {"type": "b", "children": [{"type": "t", "text": "Up-regulation of LINC00619 promotes apoptosis and inhibits proliferation, migration and invasion while promoting apoptosis of osteosarcoma cells through inactivation of the HGF-mediated PI3K-Akt signalling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epigenetics (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15592294.2021.1890873"}], "href": "https://doi.org/10.1080/15592294.2021.1890873"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33797312"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33797312"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiaoguang Niu, Yongtao Xu, Ni Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Weighted Gene Coexpression Network Analysis Reveals the Critical lncRNAs and mRNAs in Development of Hirschsprung's Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Comput Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/cmb.2019.0261"}], "href": "https://doi.org/10.1089/cmb.2019.0261"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31647312"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31647312"}]}]}]}