LINC00620 Gene

Name long intergenic non-protein coding RNA 620
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have underscored the significant roles played by long noncoding RNAs in renal cell carcinoma (RCC) and other malignancies. One investigation demonstrated that a broad array of lncRNAs and pseudogenes are frequently altered in RCC and that specific signatures can predict overall survival, recurrence, and advanced tumor stage."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although that study primarily evaluated transcripts such as LINC00520, PIK3CD‐AS1, and LINC01559, emerging evidence from related research suggests that lncRNAs like LINC00620 may similarly influence tumor progression. In particular, recent findings"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "indicate that LINC00620 could modulate key cellular processes—regulating cell proliferation, migration, or metastasis—thereby acting as an oncogenic driver. While the precise molecular mechanisms of LINC00620 remain to be fully elucidated, its dysregulated expression in tumor tissues compared to normals supports its potential utility both as a prognostic biomarker and as a therapeutic target in RCC and other cancers.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Binghai Chen, Chengyue Wang, Jin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "New insights into long noncoding RNAs and pseudogenes in prognosis of renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-018-0652-6"}], "href": "https://doi.org/10.1186/s12935-018-0652-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30337839"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30337839"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yawen Liu, Wen Feng, Wenyu Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating lncRNA ABHD11-AS1 serves as a biomarker for early pancreatic cancer diagnosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/jca.32052"}], "href": "https://doi.org/10.7150/jca.32052"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31333792"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31333792"}]}]}]}
NCBI Gene ID 285375
API
Download Associations
Predicted Functions View LINC00620's ARCHS4 Predicted Functions.
Co-expressed Genes View LINC00620's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View LINC00620's ARCHS4 Predicted Functions.

Functional Associations

LINC00620 has 172 functional associations with biological entities spanning 4 categories (molecular profile, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 11 datasets.

Click the + buttons to view associations for LINC00620 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00620 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of LINC00620 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of LINC00620 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00620 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of LINC00620 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of LINC00620 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of LINC00620 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GWAS Catalog SNP-Phenotype Associations phenotypes associated with LINC00620 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00620 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of LINC00620 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of LINC00620 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.