{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent investigations have revealed that LINC00622 plays a critical regulatory role in neuroblastoma (NB). One study demonstrated that adipose‐derived stem cell extracellular vesicles (ADSC‐Evs) deliver LINC00622 into NB cells, where it functions to inhibit the activity of the transcription factor androgen receptor (AR). This inhibition leads to the upregulation of gamma‐aminobutyric acid B-type receptor 1 (GABBR1), resulting in reduced proliferation, invasion, and migration of NB cells, as well as decreased tumor growth in vivo."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Although additional studies have broadened our understanding of long non-coding RNAs in other disease contexts—such as Alzheimer’s disease, where lncRNAs and their binding proteins have been implicated in pathogenic mechanisms"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", and fibrosis, where altered lncRNA expression has been observed during fibroblast activation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "—the evidence specifically indicates that LINC00622 contributes to tumor suppression in NB by modulating the AR/GABBR1 axis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mengguo Guo, Dongpeng Li, Yawen Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Adipose-derived stem cell-derived extracellular vesicles inhibit neuroblastoma growth by regulating GABBR1 activity through LINC00622-mediated transcription factor AR."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Leukoc Biol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/JLB.1MIA0321-164R"}], "href": "https://doi.org/10.1002/JLB.1MIA0321-164R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34448502"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34448502"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Tingting Yan, Feng Ding, Yan Zhao "}, {"type": "b", "children": [{"type": "t", "text": "Integrated identification of key genes and pathways in Alzheimer's disease via comprehensive bioinformatical analyses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hereditas (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s41065-019-0101-0"}], "href": "https://doi.org/10.1186/s41065-019-0101-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31346329"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31346329"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mirolyuba Ilieva, Henry E Miller, Arav Agarwal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FibroDB: Expression Analysis of Protein-Coding and Long Non-Coding RNA Genes in Fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Noncoding RNA (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ncrna8010013"}], "href": "https://doi.org/10.3390/ncrna8010013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35202087"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35202087"}]}]}]}