{"type": "root", "children": [{"type": "t", "text": "<head>\n <meta charset=\"UTF-8\">\n <title>Summary of LINC00624 Function</title>\n </head>\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n LINC00624 is an antisense long noncoding RNA originating from the 1q21.1 region, a genomic locus also implicated in neurodevelopmental evolution."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In hepatocellular carcinoma, LINC00624 is transcriptionally activated alongside neighboring oncogenes, and its overexpression promotes tumor growth and metastasis. Mechanistic studies show that LINC00624 functions as a molecular decoy by binding to the RBCC domain of TRIM28 and interfering with the assembly of the HDAC6–TRIM28–ZNF354C transcriptional corepressor complex. This disruption results in the release of CHD1L and BCL9 promoters from repression, thereby facilitating their increased transcription."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In prostate cancer, elevated levels of LINC00624 correlate with poor prognosis, and its knockdown diminishes the proliferative and migratory capacities of cancer cells. Here, LINC00624 partners with TEX10 to co-regulate NF-κB signaling, further underlining its oncogenic role."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Together, these findings elucidate the multifaceted oncogenic functions of LINC00624 across different tumor types and underscore its potential as a novel biomarker and therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ian T Fiddes, Gerrald A Lodewijk, Meghan Mooring, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2018.03.051"}], "href": "https://doi.org/10.1016/j.cell.2018.03.051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29856954"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29856954"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhe Li, Xinyuan Lu, Yanfang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gain of LINC00624 Enhances Liver Cancer Progression by Disrupting the Histone Deacetylase 6/Tripartite Motif Containing 28/Zinc Finger Protein 354C Corepressor Complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.31530"}], "href": "https://doi.org/10.1002/hep.31530"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32869873"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32869873"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jian Zhou, Juan Li, Chunya Qian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00624/TEX10/NF-κB axis promotes proliferation and migration of human prostate cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2022.02.078"}], "href": "https://doi.org/10.1016/j.bbrc.2022.02.078"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35219000"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35219000"}]}]}]}