{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00628 is a long non‐coding RNA with context‐dependent roles in cancer that have been highlighted across several studies. In osteosarcoma, gastric cancer, colorectal cancer, hepatocellular carcinoma, and breast cancer, LINC00628 is downregulated and acts as a tumor suppressor by inhibiting cell proliferation, migration, and invasion while promoting cell cycle arrest and apoptosis. Mechanistically, these tumor suppressive effects are mediated at least in part by the modulation of key signaling pathways, including the inactivation of PI3K/Akt signaling, and by epigenetic regulation through its interaction with chromatin modifiers such as enhancer of zeste homolog 2 (EZH2) to alter H3K27me3 levels or upregulate cell cycle regulators like p57, as well as by repressing the promoter activity of genes such as vascular endothelial growth factor A (VEGFA) ("}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": ")."}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In contrast, studies in lung adenocarcinoma reveal an oncogenic facet for LINC00628. Here, LINC00628 is overexpressed and appears to promote cancer progression by recruiting DNA methyltransferases (DNMTs) to facilitate hypermethylation of target gene promoters (for example, the LAMA3 promoter), thereby enhancing cell proliferation, migration, invasion, and chemoresistance ("}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ")."}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, LINC00628 is implicated in broader regulatory networks. Its nuclear localization and interaction with epigenetic modulators, including EZH2, enable it to exert long‐range effects on the expression of cell cycle–related genes and contribute to gene regulatory architectures, as illustrated by its inclusion in a chromatin regulatory archipelago alongside other functionally related genes ("}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "). Such multifaceted functions position LINC00628 as a promising prognostic biomarker and potential therapeutic target in a variety of cancer types.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "R He, J-X Wu, Y Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LINC00628 overexpression inhibits the growth and invasion through regulating PI3K/Akt signaling pathway in osteosarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201809_15915"}], "href": "https://doi.org/10.26355/eurrev_201809_15915"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30280767"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30280767"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zi-Zhen Zhang, Gang Zhao, Chun Zhuang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC00628 functions as a gastric cancer suppressor via long-range modulating the expression of cell cycle related genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep27435"}], "href": "https://doi.org/10.1038/srep27435"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27272474"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27272474"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "M-C Zhang, L Zhang, M-Q Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulated LINC00628 aggravates the progression of colorectal cancer via inhibiting p57 level."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202002_20353"}], "href": "https://doi.org/10.26355/eurrev_202002_20353"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32141544"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32141544"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Qiuxu Chen, Dan Wang, Yongguo Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00628 suppresses migration and invasion of hepatocellular carcinoma by its conserved region interacting with the promoter of VEGFA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.28233"}], "href": "https://doi.org/10.1002/jcp.28233"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30740671"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30740671"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "D-Q Chen, X-D Zheng, Y Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC00628 suppresses the growth and metastasis and promotes cell apoptosis in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2017)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28165561"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28165561"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Tingting Liu, Shuangshuang Xu, Xiaoxin Liu "}, {"type": "b", "children": [{"type": "t", "text": "LINC00628 is differentially expressed between lung adenocarcinoma and squamous cell carcinoma and is associated with the prognosis of NSCLC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Lett (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ol.2021.13173"}], "href": "https://doi.org/10.3892/ol.2021.13173"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34992687"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34992687"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Shu-Feng Xu, Yue Zheng, Ling Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Non-coding RNA LINC00628 Interacts Epigenetically with the LAMA3 Promoter and Contributes to Lung Adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Ther Nucleic Acids (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.omtn.2019.08.005"}], "href": "https://doi.org/10.1016/j.omtn.2019.08.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31557618"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31557618"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ke-Sin Yan, Chia-Yuan Lin, Tan-Wei Liao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EZH2 in Cancer Progression and Potential Application in Cancer Therapy: A Friend or Foe?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms18061172"}], "href": "https://doi.org/10.3390/ijms18061172"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28561778"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28561778"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Timothy A Donlon, Brian J Morris "}, {"type": "b", "children": [{"type": "t", "text": "In silico analysis of human renin gene-gene interactions and neighborhood topologically associated domains suggests breakdown of insulators contribute to ageing-associated diseases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biogerontology (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10522-019-09834-1"}], "href": "https://doi.org/10.1007/s10522-019-09834-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31520345"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31520345"}]}]}]}