| Name | long intergenic non-protein coding RNA 629 |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00629 is a long intergenic noncoding RNA that is prominently expressed in reproductive tissues, including the placenta, and appears to exert tumor‐suppressive functions in cancer. In a choriocarcinoma in vitro model, overexpression of the three‐exon LINC00629 isoforms was shown to reduce cell migration and invasion, suggesting an inhibitory role in tumor progression associated with reproductive tissues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In gastric cancer, LINC00629 expression is diminished, and its forced overexpression led to reduced proliferation, invasion, and migration of cancer cells. Mechanistically, LINC00629 functions as a competing endogenous RNA by binding to miR-196b-5p, which in turn upregulates the expression of the tumor suppressor aquaporin 4 (AQP4), thereby mitigating cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n These data collectively suggest that LINC00629 may serve as both a novel biomarker and a potential therapeutic target in cancers related to reproductive tissues.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Bruna Rodrigues Muys, Júlio Cesar Cetrulo Lorenzi, Dalila Luciola Zanette, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0151560"}], "href": "https://doi.org/10.1371/journal.pone.0151560"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27023770"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27023770"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jun Li, Lei Wang, Fang He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LINC00629 restrains the progression of gastric cancer by upregulating AQP4 through competitively binding to miR-196b-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29203"}], "href": "https://doi.org/10.1002/jcp.29203"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31674022"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31674022"}]}]}]}
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| Synonyms | LINC00629B, LINC00629D, LINC00629A, LINC00629C |
| NCBI Gene ID | 100506757 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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LINC00629 has 367 functional associations with biological entities spanning 3 categories (disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 10 datasets.
Click the + buttons to view associations for LINC00629 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of LINC00629 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of LINC00629 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of LINC00629 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of LINC00629 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of LINC00629 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of LINC00629 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of LINC00629 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of LINC00629 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of LINC00629 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of LINC00629 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
