{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00630 is a long non‐coding RNA that has emerged as a multifunctional regulator in several pathological conditions, especially in various cancers. In non‐small‐cell lung cancer, LINC00630 is markedly upregulated and promotes tumor proliferation and metastasis through its interaction with proteins such as DDX23 and by stabilizing HDAC1, thereby influencing downstream signaling pathways critical for tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In hepatocellular carcinoma, the oncogenic effects of LINC00630 are mediated by its direct binding to the transcription factor E2F1, which enhances the transcription of CDK2 and facilitates cell cycle progression, resulting in increased tumor cell proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its role in malignancies, LINC00630 is also implicated in other pathological contexts. It is part of a competing endogenous RNA network identified in studies of irreversible pulpitis, suggesting its contribution to inflammatory and regulatory processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In colon carcinoma, LINC00630 functions as a molecular sponge for miR-409-3p, leading to upregulation of hexokinase 2 (HK2), which in turn promotes glycolysis, cell growth, and resistance to apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Similarly, in cholangiocarcinoma LINC00630 promotes proliferation, migration, and invasion by sponging miR-199a and thereby upregulating fibroblast growth factor 7 (FGF7)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n LINC00630’s clinical relevance is further underscored by its inclusion in an eight-lncRNA prognostic signature for childhood acute lymphoblastic leukemia, highlighting its potential as a prognostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Additionally, its association with radiotherapy response—being one of several lncRNAs whose expression correlates with treatment outcomes—reflects its broader involvement in determining radiosensitivity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In colorectal cancer, elevated levels of LINC00630 contribute to radioresistance by associating with EZH2 to epigenetically repress the expression of BEX1, thus diminishing apoptosis and supporting tumor cell survival upon irradiation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings indicate that LINC00630 plays diverse oncogenic roles—ranging from promoting cell proliferation, migration, and metabolic reprogramming to modulating treatment resistance—through interactions with transcription factors, epigenetic modifiers, and microRNAs. Its multifaceted functions and consistent upregulation in multiple disease contexts make it a promising molecular target for diagnostic, prognostic, and therapeutic strategies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Guozhang Mao, Hui Jin, Liuguang Wu "}, {"type": "b", "children": [{"type": "t", "text": "DDX23-Linc00630-HDAC1 axis activates the Notch pathway to promote metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.17156"}], "href": "https://doi.org/10.18632/oncotarget.17156"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28473661"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28473661"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jian Kang, Xu Huang, Weiguo Dong, et al. 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