{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00632, a long non‐coding RNA, has emerged as a critical regulatory hub that modulates both circular RNA biogenesis and microRNA activity in diverse disease contexts. In melanoma, for example, epigenetic silencing of LINC00632 suppresses production of its derivative circRNA (CDR1as/ciRS-7), thereby promoting invasion and metastasis through an IGF2BP3‐mediated, miR-7–independent mechanism."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n In non–small cell lung cancer, reduced LINC00632 expression correlates with enhanced lymph node metastasis, distant spread, and poor prognosis, while its overexpression impairs cell proliferation and migration by negatively regulating miR-1203."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its oncologic roles, LINC00632 functions as an important immunomodulator in allergic rhinitis. In nasal epithelial cells, it is downregulated upon IL-13 stimulation, and its overexpression counteracts IL-13–induced production of pro-inflammatory cytokines by interacting with EZH2 to repress GATA-3 and by targeting miR-498."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Integrative transcriptomic analyses have further implicated LINC00632 as a prognostic marker in both neuroblastoma and tamoxifen-treated breast cancer, thereby linking its expression to overall patient survival and therapeutic response."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n Moreover, genomic deletions that encompass LINC00632—as observed in hemophilia B patients with intellectual disability—suggest that loss of this locus may contribute to broader developmental phenotypes"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ", while analyses of competitive endogenous RNA networks in intrauterine adhesion indicate potential additional regulatory roles."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings highlight LINC00632 as a multifunctional RNA that, through epigenetic modulation and interactions with various RNA species and chromatin regulators, acts as a tumor suppressor and immune regulator. Its diverse roles in controlling metastasis, therapeutic response, and inflammatory processes underscore its potential as both a prognostic biomarker and a candidate therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Douglas Hanniford, Alejandro Ulloa-Morales, Alcida Karz, et al. 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