{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have identified LINC00635 as a long non‐coding RNA with potential regulatory functions in diverse biological contexts. In analyses of human germ cells, LINC00635 was among a panel of lncRNAs showing consistent differential expression during spermatogenesis, suggesting it may play a role in the regulation of germ cell development and maturation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, LINC00635 has been incorporated into a prognostic transcript signature for pancreatic ductal adenocarcinoma; its altered expression in pancreatic cancer cells correlated with changes in pathways involved in cell adhesion, proteolysis, and secretion, indicating that LINC00635 may contribute to tumor progression and serve as a potential biomarker for patient outcome."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings highlight LINC00635’s dual relevance in reproductive biology and oncology, underscoring its promise both as a diagnostic and prognostic marker. Further studies are warranted to elucidate the precise molecular mechanisms by which LINC00635 influences spermatogenesis and tumorigenesis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Meghali Joshi, Singh Rajender "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNAs (lncRNAs) in spermatogenesis and male infertility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Biol Endocrinol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12958-020-00660-6"}], "href": "https://doi.org/10.1186/s12958-020-00660-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33126901"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33126901"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yingcheng Wu, Jinhuan Wei, Yue Ming, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Orchestrating a biomarker panel with lncRNAs and mRNAs for predicting survival in pancreatic ductal adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.27119"}], "href": "https://doi.org/10.1002/jcb.27119"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29923223"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29923223"}]}]}]}