{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have implicated the long non‐coding RNA LINC00636 in diverse pathological processes across multiple organ systems. In patients with atrial fibrillation and myocardial fibrosis, LINC00636 was identified as having a regulatory relationship with miR‑450a‑2‑3p – suggesting a potential role in modulating fibrotic responses, possibly through TGF‑β–related pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In HER‑2–enriched subtype breast cancer, network analyses have highlighted LINC00636 as one of the core genes co‐expressed with other lncRNAs and mRNAs implicated in key signaling cascades such as MAPK and PI3K‑Akt, indicating its possible involvement in tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, in cervical cancer, elevated serum and tumor levels of LINC00636 were associated with metastasis; functional experiments revealed that knockdown of LINC00636 suppressed cell invasion and proliferation, likely by alleviating its inhibitory effect on the metastasis‐suppressor gene NM23."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Finally, in pancreatic ductal adenocarcinoma, LINC00636 emerged as a component of a prognostic lncRNA–mRNA panel linked to pathways such as cell adhesion and proteolysis, suggesting its utility as a biomarker and hinting at a functional role in the molecular pathogenesis of this aggressive cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Langsha Liu, Fanyan Luo, Kaibo Lei "}, {"type": "b", "children": [{"type": "t", "text": "Exosomes Containing LINC00636 Inhibit MAPK1 through the miR-450a-2-3p Overexpression in Human Pericardial Fluid and Improve Cardiac Fibrosis in Patients with Atrial Fibrillation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mediators Inflamm (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/9960241"}], "href": "https://doi.org/10.1155/2021/9960241"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34257520"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34257520"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Fan Yang, Shixu Lyu, Siyang Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression profile analysis of long noncoding RNA in HER-2-enriched subtype breast cancer by next-generation sequencing and bioinformatics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S97664"}], "href": "https://doi.org/10.2147/OTT.S97664"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26929647"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26929647"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yue Zhong, Qiang Lu, Wei Qiu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00636 promotes lymph node metastasis and cervical cancer through targeting NM23."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20200367"}], "href": "https://doi.org/10.1042/BSR20200367"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33034616"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33034616"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yingcheng Wu, Jinhuan Wei, Yue Ming, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Orchestrating a biomarker panel with lncRNAs and mRNAs for predicting survival in pancreatic ductal adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.27119"}], "href": "https://doi.org/10.1002/jcb.27119"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29923223"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29923223"}]}]}]}