{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00638 is a long non‐coding RNA that appears to play multifaceted roles in regulating inflammatory responses, oxidative stress, and immune modulation across several disease contexts. In rheumatoid arthritis (RA), studies have demonstrated that LINC00638 is down‐regulated in peripheral blood mononuclear cells and in fibroblast-like synoviocytes. Its reduced expression is associated with enhanced inflammatory cytokines and heightened oxidative stress, whereas its overexpression can down-regulate pro-inflammatory mediators (e.g., TNF-α, IL-6) and up-regulate anti-inflammatory factors (e.g., IL-4, IL-10) as well as antioxidant enzymes, suggesting a protective role against RA progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In hepatocellular carcinoma (HCC), LINC00638 is incorporated into an eight-lncRNA prognostic model and is implicated in a ceRNA network, specifically forming the LINC00638/miR-4732-3p/ULBP1 axis. This axis is proposed to regulate natural killer cell infiltration and may contribute to immune escape mechanisms associated with high tumor mutation burden, thereby correlating with a poorer prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, LINC00638 has emerged as one of the key molecules linked to altered self-perception in RA patients, indicating that its dysregulated expression may reflect or contribute to patient-reported outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Similarly, in the context of neonatal sepsis, LINC00638 is identified as a hub node within a competing endogenous RNA network enriched for immune-related functions, underscoring its potential as a diagnostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Lastly, bioinformatics analyses in lumbar disc degeneration have recognized LINC00638 as one of the key regulatory lncRNAs involved in pathways related to cellular organization, gene expression, and metabolic regulation, further supporting its role in disease progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Y Sun, J Liu, L Xin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[The low expression of long non-coding RNA Linc00638 contributes to rheumatoid arthritis progression by regulating inflammation and oxidative stress]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nan Fang Yi Ke Da Xue Xue Bao (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12122/j.issn.1673-4254.2021.07.01"}], "href": "https://doi.org/10.12122/j.issn.1673-4254.2021.07.01"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34308844"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34308844"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yanqiu Sun, Jian Liu, Qin Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of LINC00638 in rheumatoid arthritis patients with damp-heat obstruction syndrome and the regulatory mechanisms for inflammation and oxidative stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhong Nan Da Xue Xue Bao Yi Xue Ban (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.11817/j.issn.1672-7347.2022.210376"}], "href": "https://doi.org/10.11817/j.issn.1672-7347.2022.210376"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35545408"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35545408"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jianting Wen, Jian Liu, Bing Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prediction of Self-Perception of Patient in Rheumatoid Arthritis With the Key RNAs Expression Profiles."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Med (Lausanne) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fmed.2020.00567"}], "href": "https://doi.org/10.3389/fmed.2020.00567"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33072778"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33072778"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Feng Qi, Xiaojing Du, Zhiying Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor Mutation Burden-Associated LINC00638/miR-4732-3p/ULBP1 Axis Promotes Immune Escape "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "via"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " PD-L1 in Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2021.729340"}], "href": "https://doi.org/10.3389/fonc.2021.729340"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34568062"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34568062"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ling Liu, Hong Wang, Xiaofei Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Potential Biomarkers in Neonatal Sepsis by Establishing a Competitive Endogenous RNA Network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Comb Chem High Throughput Screen (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/1386207323666200401121204"}], "href": "https://doi.org/10.2174/1386207323666200401121204"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32233999"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32233999"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Y-H Zhang, J Song, L Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Systematic identification of lncRNAs and circRNAs-associated ceRNA networks in human lumbar disc degeneration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biotech Histochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/10520295.2019.1622782"}], "href": "https://doi.org/10.1080/10520295.2019.1622782"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31271316"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31271316"}]}]}]}