{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have highlighted the involvement of long non‐coding RNAs in diverse human diseases. In a genome‐wide association study of non‐syndromic cleft lip with palate, LINC00640 was identified among several genomic loci associated with an increased risk of developing this common craniofacial malformation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although the precise molecular function of LINC00640 remains to be elucidated, its inclusion as a susceptibility locus suggests that it may have a regulatory role in craniofacial development or related biological pathways. In contrast, an independent study investigating Kaposi’s sarcoma-associated herpesvirus reactivation uncovered a distinct long non-coding RNA, LINC00313, which acts as an angiogenic repressor in endothelial cells and whose activity is counteracted by the HIV Tat protein."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Together, these findings underscore the multifaceted contributions of long non-coding RNAs in human pathology, with LINC00640 potentially impacting developmental processes that lead to craniofacial malformations.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yanqin Yu, Xianbo Zuo, Miao He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide analyses of non-syndromic cleft lip with palate identify 14 novel loci and genetic heterogeneity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms14364"}], "href": "https://doi.org/10.1038/ncomms14364"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28232668"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28232668"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wan-Shan Yang, Ting-Yu Lin, Lung Chang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HIV-1 Tat Interacts with a Kaposi's Sarcoma-Associated Herpesvirus Reactivation-Upregulated Antiangiogenic Long Noncoding RNA, LINC00313, and Antagonizes Its Function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.01280-19"}], "href": "https://doi.org/10.1128/JVI.01280-19"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31723026"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31723026"}]}]}]}