{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00641 is a long non‐coding RNA whose dysregulated expression has been implicated in a broad range of pathological conditions, most notably in multiple cancer types as well as in several non‐neoplastic disorders. In some cancers, such as bladder cancer, non‐small cell lung cancer, breast cancer, acute myeloid leukemia, cervical cancer, prostate cancer, and glioma, LINC00641 is frequently down‐regulated and its overexpression suppresses malignant behaviors by inhibiting cell proliferation, migration, invasion and promoting apoptosis. Mechanistically, LINC00641 functions principally as a competing endogenous RNA (ceRNA) by “sponging” various oncogenic microRNAs—including miR‐197‑3p, miR‑424‑5p, miR‑194‑5p, miR‑378a, miR‑378a‑3p, miR‑340‑5p, miR‑320a, miR‑365a‑3p, miR‑497‑5p and miR‑4262—to restore tumor‐suppressor gene expression (for example, KLF10, PLSCR4, CPEB3, ZBTB20, VGLL4, NRGN, and BDNF) and to modulate critical signaling pathways such as the PTEN/PI3K/AKT, Notch‐1 and TrkB/PI3K/Akt pathways (1,3,4,6,7,8,12,18,21). "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In contrast, in certain cancers, including some studies of gastric and colorectal adenocarcinomas, LINC00641 appears to be overexpressed and to promote malignant progression by enhancing cell viability, migration, autophagy and chemoresistance through different ceRNA axes (sponging miR‑582‑5p or miR‑429 to upregulate targets such as Notch‑1 or PRKG1) (5,9,11). Even in non‐tumor conditions, such as intervertebral disc degeneration, diabetic foot ulcers, and ketamine‐induced neural injury, LINC00641 exhibits important regulatory roles by influencing autophagic cell death and neuroprotection via its interactions with microRNAs (2,17,21). "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, multiple studies have demonstrated that LINC00641 holds prognostic significance in diverse tumors—including glioma, prostate, thyroid, and colon cancers—as it is frequently incorporated into prognostic or ferroptosis‐/pyroptosis‐related lncRNA signatures; its expression level correlates with tumor stage, overall survival, or therapy response (1,4,7,8,13,14,16,19,20,22,23,24,26,27). Collectively, these findings highlight LINC00641 as a multifunctional regulatory RNA that can act either as a tumor suppressor or as an oncogene depending on the cellular context. Its involvement in various ceRNA networks and signaling pathways underscores its potential as a diagnostic biomarker and therapeutic target across a spectrum of diseases."}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "b", "children": [{"type": "t", "text": "Citations:"}]}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "27"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhijia Li, Shizhe Hong, Zhihu Liu "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LINC00641 predicts prognosis and inhibits bladder cancer progression through miR-197-3p/KLF10/PTEN/PI3K/AKT cascade."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.07.120"}], "href": "https://doi.org/10.1016/j.bbrc.2018.07.120"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30060954"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30060954"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiao-Bo Wang, Hua Wang, Hou-Qing Long, et al. 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