{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In a recent study of epigenetic alterations in acute lymphoblastic leukemia (ALL), genome‐wide analyses revealed widespread changes in DNA methylation that affected not only protein‐coding genes but also non‐coding genomic elements (1). Although the abstract does not specifically single out LINC00642 by name, its inclusion under the category of non‐coding RNAs suggests that, like other enhancer‐like intergenic elements affected by aberrant methylation, LINC00642 may participate in regulating the expression of nearby genes involved in critical cellular processes such as cell cycle control, lymphocyte activation, apoptosis, and proliferation. In this context, dysregulation of LINC00642—presumably through epigenetic modifications—could contribute to the misregulation of transcriptional programs that ultimately provide a selective advantage to leukemic cells (1)."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Md Almamun, Benjamin T Levinson, Annette C van Swaay, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrated methylome and transcriptome analysis reveals novel regulatory elements in pediatric acute lymphoblastic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epigenetics (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15592294.2015.1078050"}], "href": "https://doi.org/10.1080/15592294.2015.1078050"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26308964"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26308964"}]}]}]}