{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have highlighted the crucial role of long non‐coding RNAs in human diseases. In lung cancer, for instance, LINC00648 is significantly overexpressed, with analyses derived from TCGA data and clinical patient samples demonstrating that high levels of this lncRNA are associated with enhanced lymphatic metastasis, lower tumor differentiation, and reduced overall survival. Bioinformatic investigations further suggest that LINC00648 may function as part of a competitive endogenous RNA (ceRNA) network, interacting with multiple micro‐RNAs and their target mRNAs, thereby influencing key regulatory processes such as SMAD binding, transcriptional activation via RNA polymerase II, and various signaling pathways including Hippo, MAPK, and transforming growth factor‐beta receptor pathways (1). While lncRNA-mediated ceRNA mechanisms have also been explored in other contexts—such as in cardiac hypertrophy, where different lncRNAs have been implicated in disease progression (2)—the functional insights available for LINC00648 primarily underscore its potential as a diagnostic and prognostic biomarker in the lung cancer setting."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ling Zhao, Mingxu Gao, Xiujuan Zhao "}, {"type": "b", "children": [{"type": "t", "text": "Verification of expression of LINC00648 in the serum of lung cancer patients by TCGA database."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol (Noisy-le-grand) (2020)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32538754"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32538754"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chao Song, Jian Zhang, Yan Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Construction and analysis of cardiac hypertrophy-associated lncRNA-mRNA network based on competitive endogenous RNA reveal functional lncRNAs in cardiac hypertrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.7312"}], "href": "https://doi.org/10.18632/oncotarget.7312"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26872060"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26872060"}]}]}]}