{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00649 is a long intergenic non‐coding RNA that has emerged as an important regulator in a range of human diseases, particularly in various cancers. In gastric cancer, LINC00649 is enriched in tumor tissues and functions as an oncogene by accelerating cell proliferation, migration, and epithelial–mesenchymal transition (EMT)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In acute myeloid leukemia (AML), its aberrant expression has been incorporated into prognostic models where altered levels are associated with clinical outcomes, suggesting its utility as a prognostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, in triple‐negative breast cancer, investigations are underway to elucidate its role in promoting cellular proliferation, invasion, and migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In lung squamous cell carcinoma, LINC00649 is upregulated through transcriptional activation by E2F7; it subsequently recruits TAF15 to stabilize MAPK6 expression, thereby activating the MAPK signaling pathway and driving tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In bladder cancer, elevated LINC00649 enhances cell proliferation, migration, and invasion by acting as a molecular sponge for miR‑16‑5p, which in turn leads to the upregulation of JARID2."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Its role in colorectal cancer is similarly oncogenic: high expression levels correlate with a poor prognosis, while knockdown studies have demonstrated reduced proliferation, migration, and invasion alongside increased apoptosis, potentially via interactions with miR‑432‑5p."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond cancer, LINC00649 has also been identified in competing endogenous RNA networks related to multiple sclerosis, indicating its broader relevance in disease pathogenesis and its promise as a candidate for biomarker discovery and therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies reveal that LINC00649 exerts significant regulatory effects on key cellular processes such as proliferation, migration, invasion, and apoptosis across various malignancies and diseases. Its diverse roles not only underscore its potential as a diagnostic and prognostic biomarker but also highlight the possibility of targeting LINC00649 for therapeutic development.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hongyan Wang, Xin Di, Yingjie Bi, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LINC00649 promotes the growth and metastasis of triple-negative breast cancer by maintaining the stability of HIF-1α through the NF90/NF45 complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2022.2040283"}], "href": "https://doi.org/10.1080/15384101.2022.2040283"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35188449"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35188449"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Huaiyang Zhu, Qingyuan Liu, Xiaobo Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LINC00649 recruits TAF15 and enhances MAPK6 expression to promote the development of lung squamous cell carcinoma via activating MAPK signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Gene Ther (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41417-021-00410-9"}], "href": "https://doi.org/10.1038/s41417-021-00410-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35228660"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35228660"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yongsong Liu, Xiande Huang, Lijun Guo, et al. 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