{"type": "root", "children": [{"type": "t", "text": "<head>\n <meta charset=\"UTF-8\">\n <title>LINC00654 Function Summary</title>\n </head>\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n LINC00654 has emerged as a long non‐coding RNA with diverse associations across multiple disease settings. In breast cancer, its upregulation was found to correlate with poor overall survival, indicating a potential oncogenic role even though functional investigations were carried out for a related lncRNA in the same study (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In colorectal cancer, LINC00654 was one component of a multi‐lncRNA plasma panel that demonstrated high diagnostic performance for early detection, further emphasizing its clinical biomarker potential."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to these findings in tumor biology, LINC00654 was also identified among lncRNAs positively correlated with oncogenic drivers in ovarian cancer, suggesting a tumor‐promoting effect as part of a broader regulatory network."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Outside the realm of cancer, integrated network analyses in osteoarthritis cartilage revealed LINC00654 as one of several hub lncRNAs potentially involved in regulating extracellular matrix organization and chondrocyte homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, in IL‑1β‑treated chondrocytes, resveratrol treatment was found to upregulate LINC00654, suggesting a role in mediating the protective effects of resveratrol on chondrocyte function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Lastly, transcriptomic studies of human male germ cells have consistently reported differential expression of LINC00654, implicating it as a potential modulator in spermatogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings portray LINC00654 as a multifunctional lncRNA that is associated with oncogenic processes in breast, colorectal, and ovarian cancers, while also being linked to tissue homeostasis in osteoarthritis and potentially playing a role in the development of germ cells. Its recurrent identification across diverse studies underscores its promise both as a biomarker and as a candidate for future functional investigations.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hairong Liu, Juan Li, Pratirodh Koirala, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNAs as prognostic markers in human breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.7828"}], "href": "https://doi.org/10.18632/oncotarget.7828"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26942882"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26942882"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wei Xu, Gai Zhou, Huizhi Wang, et al. 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