{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNA LINC00659 has emerged as an oncogenic regulator in gastrointestinal malignancies, particularly colorectal and gastric cancers. In colorectal cancer, LINC00659 is overexpressed and its elevated levels correlate with poor patient survival. Functional studies have demonstrated that LINC00659 facilitates cancer cell proliferation, migration, invasion, and cell cycle progression, while its silencing induces apoptosis. Moreover, mechanistic investigations revealed that LINC00659 modulates tumor growth via multiple pathways. In one study, LINC00659 knockdown suppressed cell growth by impairing cell cycle progression and inhibiting PI3K‐AKT signaling, highlighting its role as a critical driver of colon cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, LINC00659 can be transferred to colorectal cancer cells via exosomes released from cancer‐associated fibroblasts, where it promotes epithelial–mesenchymal transition and metastasis through a miR‑342‑3p/ANXA2 regulatory axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Further supporting its oncogenic function in colon cancer, another study demonstrated that targeting LINC00659 alters the LINC00659/miR‑760 axis, thereby suppressing tumor viability, colony formation, and metastatic behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In gastric cancer, LINC00659 is markedly upregulated in tumor tissues compared with adjacent normal tissues. Its high expression is associated with advanced tumor stage, lymph node metastasis, and reduced overall patient survival. Functional experiments in gastric cancer cell lines indicate that LINC00659 promotes cell proliferation, invasion, and migration. Mechanistically, one study identified that LINC00659 directly interacts with the transcription factor SUZ12, thereby regulating cell cycle progression and facilitating tumor cell invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Furthermore, bioinformatics analyses have suggested that LINC00659 may exert its pro-metastatic effects by modulating downstream targets such as matrix metalloproteinase 15 and IQ motif-containing GTPase activating protein 3."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies underscore the multifaceted oncogenic role of LINC00659, which functions as a key regulator of cell proliferation, apoptosis, metastasis, and tumor progression through its interactions with various signaling molecules and regulatory RNAs. Its involvement in distinct molecular axes highlights its potential as both a prognostic biomarker and a therapeutic target in gastrointestinal cancers.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kuo-Wang Tsai, Yi-Hao Lo, Hsuan Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Linc00659, a long noncoding RNA, acts as novel oncogene in regulating cancer cell growth in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-018-0821-1"}], "href": "https://doi.org/10.1186/s12943-018-0821-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29523145"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29523145"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lin Zhou, Jian Li, Yaping Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal LncRNA LINC00659 transferred from cancer-associated fibroblasts promotes colorectal cancer cell progression via miR-342-3p/ANXA2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-020-02648-7"}], "href": "https://doi.org/10.1186/s12967-020-02648-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33407563"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33407563"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jianfeng Li, Yeyu Qin, Weijun Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Peiminine inhibits the progression of colorectal cancer through up-regulating miR-760 via declining the expression of long noncoding RNA LINC00659."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Drugs (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/CAD.0000000000000981"}], "href": "https://doi.org/10.1097/CAD.0000000000000981"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32740014"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32740014"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yongjia Sheng, Chenyang Han, Yi Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Correlation between LncRNA-LINC00659 and clinical prognosis in gastric cancer and study on its biological mechanism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.16069"}], "href": "https://doi.org/10.1111/jcmm.16069"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33145980"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33145980"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Pihai Gong, Ying Xu, Min Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of LINC00659 expression predicts a poor prognosis and promotes migration and invasion of gastric cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Lett (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ol.2021.12818"}], "href": "https://doi.org/10.3892/ol.2021.12818"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34084224"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34084224"}]}]}]}