{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In cholangiocarcinoma (CCA), LINC00661 is one of three autophagy‐related long noncoding RNAs identified as part of a prognostic signature that distinguishes patients with markedly different overall survival outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Elevated expression of LINC00661 in CCA tissues, relative to normal tissues, suggests its involvement in tumor progression by potentially modulating autophagy‐related pathways as well as influencing the tumor immune microenvironment. Furthermore, LINC00661 appears to participate in competing endogenous RNA networks, where it may regulate mRNA expression through interactions with specific miRNAs. This multifaceted role underscores its promise not only as a prognostic biomarker but also as a target for tailored therapeutic strategies in CCA."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ya Jun Liu, Alphonse Houssou Hounye, Zheng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and Validation of Three Autophagy-Related Long Noncoding RNAs as Prognostic Signature in Cholangiocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2021.780601"}], "href": "https://doi.org/10.3389/fonc.2021.780601"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34926294"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34926294"}]}]}]}